Event
An unmapped toxic mechanism in neurodegeneration-Inhibition of protein folding chaperones by neurotoxic dipeptide repeats| Title of the event | An unmapped toxic mechanism in neurodegeneration-Inhibition of protein folding chaperones by neurotoxic dipeptide repeats |
| Series | campus seminar |
| Organizer | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Speaker | Maria Babu |
| Speaker institution | Group for Structure Determination of Proteins Using NMR |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | Dipeptide repeat proteins are aberrantly expressed in the brain of ALS/FTD patients due to a mutation in the C9orf72 gene. The neurotoxic mechanism of these dipeptide repeats is associated to their anomalous interaction with cellular proteins, thus interfering with several physiological pathways. We explored a new toxic mechanism of dipeptide repeats that is linked to the inhibition of prolyl isomerases (a class of protein folding chaperones) that disrupt protein homeostasis. |
| Date | Start: 24.11.2021, 11:00 Uhr Ende: 24.11.2021 , 12:00 Uhr |
| Location |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Manfred Eigen Hall & Online |
| Contact |
Stefan Glöggler stefan.gloeggler@mpibpc.mpg.de |