Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Schmidt, Manuela, Dr.


  • Since 2012: Emmy Noether Group Leader
  • 2007-2012: Postdoc with Ardem Patapoutian, The Scripps Research Institute, La Jolla, California, USA
  • 2002-2006: PhD, Neurosciences, International Max Planck School Neurosciences, Laboratory of Stephan Sigrist, ENI-G, Goettingen, Germany
  • 2001-2002: Master, Neurosciences, International Max Planck School Neurosciences, Goettingen, Germany
  • 1997-2002: Diploma, Biology, University of Wuerzburg, Germany




Major Research Interests

The perception of and appropriate reaction to external and internal stimuli is critical for survival. In vertebrates, chemical, mechanical (from pleasant touch to painful contact) and thermal stimuli are detected by specialized somatic sensory neurons which transfer these signals via the spinal cord to the brain. An important subset of these neurons, so-called nociceptors, senses noxious stimuli. Consequently, their activation mediates nociception and leads to the sensation of pain. Pain is the single most common symptom for which patients seek medical assistance. While acute pain has served as a protective mechanism throughout evolution to guard the body against injury, pain can also become chronic and highly debilitating. Unfortunately, chronic pain imposes substantial challenges to medical practice: current therapies can be effective for short-term treatment however many do not provide sufficient relief to chronic conditions or cause strong side-effects. Therefore, a deeper understanding of the specific molecular mechanisms underlying both, acute and chronic pain is crucially needed. Our research focuses on the comparative and quantitative analysis of somatosensory signaling networks in established mouse models of acute and chronic pain. To this purpose our lab employs an integrative approach from comprehensive proteome profiling via mass spectrometry, biochemistry, calcium-imaging, and electrophysiology to virus-mediated gene transfer in mice and mouse behavioral studies.


Homepage Department/Research Group

http://www.em.mpg.de/index.php?id=311



Selected Recent Publications



  • Barry et al. (2018) Region resolved quantitative proteome profiling reveals molecular dynamics associated with chronic pain in the PNS and spinal cord. Frontiers Molecular Neuroscience
  • David Gomez-Varela and Manuela Schmidt (2018) The proteomics and metabolomics of pain—opportunities for systems medicine. The Oxford Handbook of the Neurobiology of Pain Edited by John N. Wood, Subject: Neuroscience, Sensory and Motor Systems
  • Narayanan P, Hütte M, Kudryasheva G, Taberner FJ, Lechner SG, Rehfeldt F, Gomez-Varela D, Schmidt M (2018) Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. Elife. 7, e32346-e32346
  • Bruderer R, Sondermann J, Tsou CC, Barrantes-Freer A, Stadelmann C, Nesvizhskii AI, Schmidt M, Reiter L, Gomez-Varela D (2017) New targeted approaches for the quantification of data-independent acquisition mass spectrometry.Proteomics [Epub ahead of print]
  • Gomez-Varela D, Schmidt M (2016) Exploring novel paths towards protein signatures of chronic pain.Mol Pain. 12, 1744806916679658-1744806916679658
  • Narayanan P, Sondermann J, Rouwette T, Karaca S, Urlaub H, Mitkovski M, Gomez-Varela D, Schmidt M (2016) Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons. J Proteome Res. 15, 2676-2687
  • Avenali L, Abate Fulas O, Sondermann J, Narayanan P, Gomez-Varela D, Schmidt M (2016) Nocistatin sensitizes TRPA1 channels in peripheral sensory neurons. Channels (Austin). [Epub ahead of print]
  • Rouwette T, Sondermann J, Avenali L, Gomez-Varela D, Schmidt M (2016) Standardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic Pain. Mol Cell Proteomics. 15, 2152-2168