Schmidt, Manuela, Prof. Dr.
- Since 2019: W2-Professor at the Faculty of Biology and Psychology, University of Goettingen
- Since 2012: Emmy Noether Group Leader
- 2007-2012: Postdoc with Ardem Patapoutian, The Scripps Research Institute, La Jolla, California, USA
- 2002-2006: PhD, Neurosciences, International Max Planck School Neurosciences, Laboratory of Stephan Sigrist, ENI-G, Goettingen, Germany
- 2001-2002: Master, Neurosciences, International Max Planck School Neurosciences, Goettingen, Germany
- 1997-2002: Diploma, Biology, University of Wuerzburg, Germany
Major Research Interests
The perception of and appropriate reaction to external and internal stimuli is critical for survival. In vertebrates, chemical, mechanical (from pleasant touch to painful contact) and thermal stimuli are detected by specialized somatic sensory neurons which transfer these signals via the spinal cord to the brain. An important subset of these neurons, so-called nociceptors, senses noxious stimuli. Consequently, their activation mediates nociception and leads to the sensation of pain. Pain is the single most common symptom for which patients seek medical assistance. While acute pain has served as a protective mechanism throughout evolution to guard the body against injury, pain can also become chronic and highly debilitating. Unfortunately, chronic pain imposes substantial challenges to medical practice: current therapies can be effective for short-term treatment however many do not provide sufficient relief to chronic conditions or cause strong side-effects. Therefore, a deeper understanding of the specific molecular mechanisms underlying both, acute and chronic pain is crucially needed. Our research focuses on the comparative and quantitative analysis of somatosensory signaling networks in established mouse models of acute and chronic pain. To this purpose our lab employs an integrative approach from comprehensive proteome profiling via mass spectrometry, biochemistry, calcium-imaging, and electrophysiology to virus-mediated gene transfer in mice and mouse behavioral studies.
Homepage Department/Research Group
Selected Recent Publications
- Sondermann JR, Barry AM, Jahn O, Michel N, Abdelaziz R, Kügler S, Gomez-Varela D, Schmidt M (2019). Vti1b promotes TRPV1 sensitization during inflammatory pain. PAIN. doi: 10.1097/j.pain.0000000000001418
- Barry AM,Sondermann JR, Sondermann JH, Gomez-Varela D and Schmidt M (2018). Region resolved quantitative proteome profiling reveals molecular dynamics associated with chronic pain in the PNS and spinal cord. Front. Mol. Neurosci. doi: 10.3389/fnmol.2018.00259
- Narayanan P, Hütte M, Kudryasheva G, Taberner FJ, Lechner S, Rehfeldt F, Gomez-Varela D, Schmidt M (2018) Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. eLife. doi: 10.7554/eLife.32346
- Bruderer R, Bernhardt OM, Gandhi T, Yuan Y, Sondermann J, Schmidt M., Gomez-Varela D, Reiter L, (2017) Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results. Mol Cell Proteomics. doi: 10.1074/mcp.RA117.000314
- Bruderer R, Sondermann J, Tsou CC, Barrantes-Freer A, Stadelmann C, Nesvizhskii AI, Schmidt M, Reiter L, Gomez-Varela D (2017) New targeted approaches for the quantification of data-independent acquisition mass spectrometry.Proteomics. doi: 10.1002/pmic.201700021
- Narayanan P, Sondermann J, Rouwette T, Karaca S, Urlaub H, Mitkovski M, Gomez-Varela D, Schmidt M. (2016). Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons. J Proteome Res, 5;15(8):2676-87. doi: 10.1021/acs.jproteome.6b00235
- Rouwette T, Sondermann J, Avenali L, Gomez-Varela D, Schmidt M. (2016). Standardized profiling of the membrane-enriched proteome of mouse dorsal root ganglia provides novel insights into chronic pain. Molecular & Cellular Proteomics, doi: 10.1074/mcp.M116.058966.
- Avenali L, Narayanan P, Rouwette T, Cervellini I, Sereda M, Gomez-Varela D, Schmidt M. (2014). Annexin A2 Regulates TRPA1-Dependent Nociception. J Neurosci. 34(44):14506-16. doi: 10.1523/JNEUROSCI.1801-14.