Event
Deciphering the role of active mechanics in cell biology, development and disease| Title of the event | Deciphering the role of active mechanics in cell biology, development and disease |
| Series | MBExC Online Lecture |
| Organizer | Cluster of Excellence Multiscale Bioimaging (MBExC) |
| Speaker | Prof. Dr. Timo Betz |
| Speaker institution | Third Institute of Physics, University of Göttingen |
| Type of event | Vortrag |
| Category | Forschung |
| Registration required | Nein |
| Details | Many biological systems rely on fundamental physical principles for their proper function. Here, mechanical processes such as force generation and adaptation of stiffness and viscosity have been very successfully used to explain complex biomedical questions with physical concepts. Such advances have been largely driven by new methods that allow to quantify biological processes and to construct theoretical models with high predictive power. I will present our recent approaches that allow to study active force generation and mobility in different biological systems over several length scales. Starting with active motion of membranes and intracellular particles in oocytes followed by cytosolic fluidification during cell division we will construct a surprisingly general description of active motion inside the cytoplasm. Turning from the subcellular to the cell and tissue scale, such mobility questions are then asked in the context of zebrafish development. Here we seek a fundamental description that enables us to explain single cell and collective migration using hydrodynamic approaches. The developed methodology can be also applied to medical questions. For example can we demonstrate that simple changes in the physical environment can switch cancer cell migration in model tumors from random, liquid like mobility to either solid or even burst like phenotypes. Here, the bursts might be a new, yet undescribed invasion mechanism. Finally, we will turn to the mechanical homeostasis of reconstructed muscle tissue. Some recent, still preliminary data triggers the hypothesis that a severe muscular dystrophy might find its origin in a deregulation of the mechanical feedback that is responsible for the tuning of the pre-tension within the muscle tissue. |
| Date | Start: 08.10.2020, 13:00 Uhr Ende: 08.10.2020 , 14:00 Uhr |
| Location | online |
| Contact |
0551 3961944 mbexc.admin@med.uni-goettingen.de |
| External link | http://www.mbexc.de |
| File attachment | 200916__MBExC Online lecture_Betz2.pdf |