Event
Shining Light on Flexible Proteins: Combining Experiments and Simulations to Tackle Intrinsic Disorder| Title of the event | Shining Light on Flexible Proteins: Combining Experiments and Simulations to Tackle Intrinsic Disorder |
| Series | campus seminar |
| Organizer | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Speaker | Gabor Nagy |
| Speaker institution | Department of Theoretical and Computational Biophysics |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | Intrinsically disordered proteins (IDPs) are proteins that do not need to fold into well-defined three-dimensional structures to perform their function. The conformational flexibility of IDP-s and intrinsically disordered regions (IDRs) in larger proteins provides functional advantages, and a detailed understanding their dynamic structures would enable new developments in medicine, biotechnology, and material science. Currently, there are no biophysical methods that can provide detailed, atomic-level information about IDPs and IDRs. Spectroscopic methods can provide valuable information on IDP structure or dynamics but often lack atomic-level details. Computer simulation methods on the other hand can provide the desired atomistic details, but their accuracy is limited by approximations and the choice of simulation parameters. Combining computer simulations and spectroscopic measurements allows to assess and to improve the accuracy of disordered protein models. We also present a few examples to show how accurate atomistic models can assist the interpretation of experimental data, and provide the molecular details to understand how IDPs and IDRs perform their functions. |
| Date | Start: 20.10.2021, 11:00 Uhr Ende: 20.10.2021 , 12:00 Uhr |
| Location |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Manfred Eigen Hall & Online |
| Contact |
Stefan Glöggler stefan.gloeggler@mpibpc.mpg.de |