Event
The proton motive force determines Escherichia coli’s robustness to extracellular pH| Title of the event | The proton motive force determines Escherichia coli’s robustness to extracellular pH |
| Series | LMP Seminar |
| Organizer | Physik lebender Materie |
| Speaker | Prof. Dr. Teuta Pilizota |
| Speaker institution | Centre for Synthetic and Systems Biology, University of Edinburgh, UK |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | Living cells can maintain their internal properties within a certain range, so-called homeostasis, e.g. intracellular pH. However, pH homeostasis has thus far not been looked at in the context of all the cellular physiological variables that are influenced by it, and the intertwined nature of these variables suggests that we need to so, to understand the homeostasis of even just one of them. Here we build a simplified mathematical model of cellular electrophysiology. We find that the strength of the PMF determines the range of extracellular pH over which the cell preserves a near-neutral cytoplasmic pH. We employ assays for time-course, single-cell, concurrent measurements of PMF and pH and find agreement with our model prediction. |
| Date | Start: 21.09.2021, 14:00 Uhr Ende: 21.09.2021 , 15:30 Uhr |
| Location |
Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS) (Am Faßberg 17) Video conference at www.zoom.us Meeting ID: 997 1155 2453 Passcode: 771001 |
| Contact |
Prof. Ramin Golestanian golestanian-office@ds.mpg.de |