Event
Chromosome morphology contributes to meiotic errors| Title of the event | Chromosome morphology contributes to meiotic errors |
| Series | campus seminar |
| Organizer | Max-Planck-Institute für Multidisziplinäre Naturwissenschaften und für Dynamik und Selbstorganisation |
| Speaker | Eirini Bellou |
| Speaker institution | Department of Meiosis |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | During fertilization, a human embryo needs to inherit precisely one copy of each chromosome from both parents. However, human eggs frequently carry an incorrect number of chromosomes, they are aneuploid. Aneuploidy is the leading cause of aberrant embryonic development, resulting in miscarriages and genetic disorders such as Down syndrome. Early cytogenetic studies have shown that aneuploidy rates during meiosis differ for individual chromosomes. The reasons for variable aneuploidy rates are unknown. In this study, I used live-cell and super-resolution microscopy to investigate the behaviour of chromosomes with high and low aneuploidy rates in both human and porcine oocytes. My results demonstrate that the architecture of the chromosomes during meiosis I affects their segregation behaviour because of the way they interact with the spindle microtubules. Together, my data provide an explanation for the high aneuploidy rates of a subset of chromosomes, and reveal a new factor that contributes to chromosome-specific aneuploidy in mammalian meiosis |
| Date | Start: 16.03.2022, 11:00 Uhr Ende: 16.03.2022 , 12:00 Uhr |
| Location |
Max-Planck-Institut für Multidisziplinäre Naturwissenschaften (MPI-NAT, Faßberg-Campus) (Am Faßberg 11) Online |
| Contact |
Stefan Glöggler stefan.gloeggler@mpibpc.mpg.de |