Event
Cryo-EM snapshots of spliceosome activation| Title of the event | Cryo-EM snapshots of spliceosome activation |
| Series | MPI Campus Seminar |
| Organizer | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Speaker | Cole Townsend |
| Speaker institution | Department of Structural Dynamics |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | Eukaryotic genes are generally transcribed as pre-mRNA, in which protein-coding exons are interrupted by non-coding introns that must be excised prior to translation. The molecular machine carrying out the removal of introns and ligation of exons to produce mature mRNA is the spliceosome, a dynamic complex consisting of 5 small nuclear ribonucleoproteins (snRNPs) and over 100 proteins. For each round of splicing, the spliceosome is assembled anew on its pre-mRNA substrate. Formation of the spliceosome’s RNA-based catalytic center occurs during activation, in which the spliceosome’s molecular architecture and composition are drastically altered. In this talk I will present cryo-EM structures of spliceosomes stalled during activation, revealing steps leading to formation of the catalytic center. |
| Date | Start: 10.02.2021, 11:00 Uhr Ende: 10.02.2021 , 12:00 Uhr |
| Location |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Online |
| Contact |
05513961108 stefan.gloeggler@mpibpc.mpg.de |