Ebert, Antje, Dr.
Research group leader at the Department of Cardiology and Pneumology
- 2010: PhD at Heidelberg University, Biochemistry Center (Graduate Research College 1188)
- 2010-2015: Postdoctoral fellow at Stanford University School of Medicine, Cardiovascular Institute (DFG fellowship); Department of Chemical and Systems Biology (Associated member)
- 2015-2016: Instructor at Stanford University School of Medicine, Cardiovascular Institute; Department of Chemical and Systems Biology (Associated member)
- since 2016: Research group leader at the University Medical Center Göttingen, Department of Cardiology and Pneumology
Major Research Interests
Molecular interactions and signaling in cardiomyopathy
Key functions in cellular metabolism and homeostasis are maintained by mitochondria. Dysfunctions in metabolic turnover and mitochondrial function contribute to many pathogenic disorders. Our group studies the interdependencies between mitochondrial function, metabolism and cellular homeostasis in cardiomyocytes and the cardiac vasculature. Particularly, we are interested in regulation of redox stress-mediated mechanisms by metabolic function and mitochondrial dynamics. We utilize a human model system of patient-specific, induced pluripotent stem cells (iPSCs), in combination with site-specific genome editing, as well as biochemical and systems biology methods. With these tools we investigate the consequences of genetic variants which cause cardiomyopathies, such as dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).
Our goals are to understand molecular signaling functions in cardiac health and disease, integrating systems medicine approaches. With our research, we aim to contribute to possible future therapeutic directions in cardiovascular disease.
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