Event
Not all anti-tumor T cell responses are generated equal| Title of the event | Not all anti-tumor T cell responses are generated equal |
| Series | Fassberg Seminar - ONLINE SEMINAR |
| Organizer | Max-Planck-Institut für biophysikalische Chemie (MPIBPC) |
| Speaker | Stefani Spranger |
| Speaker institution | MIT, Cambridge, USA |
| Type of event | Seminar |
| Category | Forschung |
| Registration required | Nein |
| Details | Cancer immunotherapies, first and foremost checkpoint blockade therapy (CBT), have revolutionized the treatment landscape of cancer patients, however, to date long-term clinical benefit is restricted to a minority of cancer patients. Responses to immunotherapy have been correlated to the presence of cytotoxic T cells within the tumor microenvironment and to the fact that these tumor-reactive killer cells have lost the functional ability to eliminate tumor cells. This terminal state of T cell differentiation is often referred to as T cell exhaustion and CBT agents can reinvigorate such exhausted T cell responses. More recently it has been appreciated that not all T cell responses follow this path of differentiation and are therefore resistant to reinvigoration by current CBT agents. We have generated mouse models which allow to study different types of T cell responses to cancer and focus particularly on the very early stages of T cell activation in the tumor-draining lymph node. |
| Date | Start: 23.03.2021, 16:00 Uhr Ende: 23.03.2021 , 17:00 Uhr |
| Location |
Max-Planck-Institut für biophysikalische Chemie (MPIBPC) (Am Faßberg 11) Zoom Online Seminar |
| Contact |
0551 201-2010 gd.office@mpibpc.mpg.de |
| File attachment | Fassberg_Announcement_ONLINE_Stefani Spranger.pdf |