Lipka, Volker, Prof. Dr.
Professor of Plant Cell Biology
- Dr. rer.nat. at the Department for Plant Molecular Biology, Technical University Aachen, 1999
- Postdoctoral fellow at the SainsburyLaboratory, John Innes Centre, Norwich, UK, 1999-2000
- Postdoctoral fellow at the Max-Planck Institute for Plant Breeding Research, Cologne, 2000-2004
- Leader of an independent research group at the Department for Plant Biochemistry, Centre for Plant Molecular Biology, University of Tübingen, 2004-2007
- Leader of an independent research group at the SainsburyLaboratory, John Innes Centre, Norwich, UK, 2007-2009
- Professor at the University of Göttingen since 2009
Major Research Interests
Our laboratory is interested in the molecular analysis of plant innate immunity. Our research is focused on 1) the molecular dissection of mechanisms that control activation of basal defence in the plant model Arabidopsis thaliana 2) the analysis of defence mechanisms that contribute to resistance against fungal pathogens 3) the identification of fungal effector molecules that interfere with the plant defence machinery and allow host plant colonization
In nature, plants are constantly exposed to above- and below-ground attack by a vast array of potential pathogens. However, most plants are immune to the majority of would-be pathogens and susceptible to only a relatively small number of adapted microbes. Using a novel plant-fungus interaction model system we recently identified several molecular components that are required for the activation (Gimenez-Ibanez et al., 2009) and execution of basal plant defence (Collins et al., 2003; Lipka et al., 2005; Stein et al., 2006; Kwon et al., 2008; Lipka et al., 2008). As a consequence, receptor-mediated recognition, pathogen-induced intracellular transport processes, dynamic organelle translocation and cytoskeletal rearrangements represent major research topics in our department. Suppression of these defence mechanisms is a key requirement for adapted pathogens and we recently began studies to identify secreted fungal effector molecules that are likely to be involved. We combine genetic, cell, molecular and biochemical experimental strategies to gain novel insights into these complex mechanisms.
Homepage Department/Research Group
Selected Recent Publications
- Willmann R, Lajunen HM, Erbs G, Newman MA, Kolb D, Tsuda K, Katagiri F, Fliegmann J, Bono JJ, Cullimore JV, Jehle AK, Götz F, Kulik A, Molinaro A, Lipka V, Gust AA, Nürnberger T (2011) Arabidopsis lysin-motif proteins LYM1 LYM3 CERK1 mediate bacterial peptidoglycan sensing and immunity to bacterial infection. Proc Nat Acad Sci USA 108(49), 19824-19829.
- Petutschnig EK, Jones AM, Serazetdinova L, Lipka U, Lipka V (2010) The Lysin Motif Receptor-like Kinase (LysM-RLK) CERK1 is a major chitin-binding protein in Arabidopsis thaliana and subject to chitin-induced phosphorylation. J Biol Chem 285(37), 28902-28911.
- Gimenez-Ibanez S, Hann DR, Ntoukakis V, Petutschnig E, Lipka V*, Rathjen JP* (2009) AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plants. Curr Biol 19, 423-429, *co-corresponding authors.
- Kwon C, Neu C, Pajonk S, Yun HS, Lipka U, Humphry ME, Bau S, Straus M, Rampelt H, El Kasmi F, Jürgens G, Parker J, Panstruga R*, Lipka V*, Schulze-Lefert P* (2008) Co-option of a default secretory pathway for plant immune responses. Nature 451, 835-840, *co-corresponding authors.
- Lipka V, Dittgen J, Bednarek P, Bhat RA, Stein M, Landtag J, Brandt W, Scheel D, Llorente F, Molina A, Wiermer M, Parker J, Somerville SC, Schulze-Lefert P (2005) Pre- and post-invasion defenses both contribute to non-host resistance in Arabidopsis. Science 310, 1180-1183.