Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Meinecke, Michael, Prof. Dr.

Group Leader Molecular Membrane Biology

  • Dr. rer. nat. University of Osnabrück (2007)
  • Postdoctoral fellow (with Harvey McMahon, MRC - Laboratory of Molecular Biology, Cambridge, UK) (2008-2012)
  • Independent group leader at the Department of Biochemistry II, University Medical Center Göttingen (since 2012)
  • Junior Professor of Molecular Membrane Biology at the European Neuroscience Institute Göttingen (since 2013)
  • Professor of Membranebiochemistry at the Department of Cellular Biochemistry, University Medical Center Göttingen (since 2017)

Major Research Interests

Biological membranes exhibit a wide variety of shapes associated with particular functions. These give rise to the complex and beautiful forms observed within cells and their organelles. Our group is interested in the fundamental molecular principles that lead to these shapes. We study the effects that membrane proteins have on membrane structures. We are also interested in the effects that different membrane morphologies have on the distribution and localization of membrane proteins into clusters and micro-domains. Taking a multi-disciplinary approach, we use model membranes to reconstitute the structure and function of organelles in vitro and then correlate these results with in vivo imaging techniques.
One class of membrane proteins we are particularly interested in are ion-channels. Ion-channels cover a large variety of different molecular functions. Well-studied examples are protein translocases, potassium channels and bacterial pore forming toxins. We use biochemical and biophysical approaches to study the function and regulation of ion-channels on a single molecule level.

Homepage Department/Research Group


Selected Recent Publications

  • Tarasenko D, Barbot M, Jans DC, Kroppen B, Sadowski B, Heim G, Möbius W, Jakobs S, Meinecke M (2017) The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology. Journal of Cell Biology 216, 889-899
  • Barbot M, Jans DC, Schulz C, Denkert N, Kroppen B, Hoppert M, Jakobs S, Meinecke M (2015) Mic10 oligomerizes tob end mitochondrial inner membranes at cristae junctions. Cell Metabolism 21, 756-763
  • Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R (2010) The Peroxisomal Importomer Constitutes a Large and Highly Dynamic Pore. Nature Cell Biology 12, 273-277
  • Henne WH, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010) FCHo proteins are nucleators of clathrin-mediated endocytosis. Science 328, 1281-1284
  • Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N, Wiedemann N (2008) Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell 132, 1011-1024
  • van der Laan, M. Meinecke, M., Dudek, J., Hutu, D.P., Lind, M., Perschil, I., Guiard, B., Wagner, R., Pfanner, N., Rehling, P. (2007) Motor-free mitochondrial presequence translocase drives membrane integration of preproteins, Nature Cell Biology 9, 1155-1159
  • Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick,D.U., Hutu,D.P., Voos, W., Truscott, K., Chacinska, A., Pfanner, N., Rehling, P. (2006) Tim50 Maintains the Permeability Barrier of the Mitochondrial Inner Membrane. Science 312, 1523-1526