PŲhlmann, Stefan, Prof. Dr.
Professor, Head of the Infection Biology Unit, German Primate Center
- 2000: Ph.D., Friedrich-Alexander-Universität Erlangen-Nürnberg
- 2000-2003: Postdoctoral Fellow, University of Pennsylvania
- 2003-2007: Head of a SFB Junior Research Group, Institute of Clinical and Molecular Virology, Friedrich-Alexander-University Erlangen-Nürnberg
- 2007-2010: Professor for Experimental Virology, Hannover Medical School
- 2010: Professor and Head of the Infection Biology Unit of the German Primate Center
Major Research Interests
The Infection Biology Unit investigates virus host cell interactions with a focus on the first step of the infection process, viral entry into target cells.
Emerging viruses, like the Middle East Respiratory Syndrome (MERS) coronavirus, can pose a serious threat to public health. Activation by host cell proteases is essential for infectivity of many emerging viruses. We are elucidating which proteolytic systems are hijacked by emerging corona-, filo-, bunya- and influenza viruses for activation. On the basis of this information we will identify inhibitors and evaluate their antiviral activity in cell culture and animal models. Moreover, we are interested in defining which host cell receptors are used by emerging viruses for cellular entry. Finally, we are investigating how interferon-induced antiviral effector molecules inhibit infection by emerging viruses.
Human immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency syndrome (AIDS), a major global health crisis We seek to understand how the composition of the glycan coat of the HIV envelope protein modulates viral spread in and between individuals. This question will be addressed by employing simian immunodeficiency virus (SIV) infection of macaques as model system for HIV infection of humans.
Homepage Department/Research Group
Selected Recent Publications
- Solomon Tsegaye T, Gnirß K, Rahe-Meyer N, Kiene M, Krämer-Kühl A, Behrens G, Münch J, Pöhlmann S (2013) Platelet activation suppresses HIV-1 infection of T cells. Retrovirology 10, 48
- Hofmann H, Li X, Zhang X, Liu W, Kühl A, Kaup F, Soldan SS, GonzŠlez-Scarano F, Weber F, He X, Pöhlmann S (2013) Severe Fever with Thrombocytopenia Virus Glycoproteins Are Targeted by Neutralizing Antibodies and Can Use DC-SIGN as a Receptor for pH-Dependent Entry into Human and Animal Cell Lines. J Virol 87, 4384-94
- Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S (2013) The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies. J Virol 87, 5502-11
- Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S (2013) TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. J Virol 87, 6150-60
- Kühl A, Münch J, Sauter D, Bertram S, Glowacka I, Steffen I, Specht A, Hofmann H, Schneider H, Behrens G, Pöhlmann S (2010) Calcium-modulating cyclophilin ligand does not restrict retrovirus release. Nat Med 16, 155-6