Soeding, Johannes, Dr.
Research Group Leader at the Max Planck Institute for Biophysical Chemistry
- 1988 -1994 Studies of physics and maths at Universities of Munich (LMU), Sussex (UK), and Heidelberg
- 1992 Diploma in physics at the University of Heidelberg
- 1994 - 1997 PhD thesis work with Rudi Grimm at the Max-Planck-Institute for Nuclear Physics in Heidelberg
- 1996 PhD in physics at the University of Heidelberg
- 1996 - 1998 Post-doc with C. Cohen-Tannoudji and J. Dalibard at the École Normale Supérieure in Paris
- 1999 - 2002 Strategy management consultant for the Boston Consulting Group in Frankfurt
- 2002 - 2007 Staff scientist with Andrei Lupas at the Max-Planck-Institute for Developmental Biology in Tuebingen
- 2007 - 2013 Group leader at the Gene Center and Department of Biochemistry, University of Munich (LMU)
- Since 2014 Group Leader of the Computational Biology Group at the Max Planck Institute of Biophysical Chemistry
Major Research Interests
Computational Biology Research Group
We are interested in two broad areas of research. First, we develop computational methods for predicting the structure, function, and evolution of proteins from sequence. We develop statistical methods that enable us to make use of the vast amount of sequence information that is becoming available at an ever-increasing pace. The goal is to provide life scientists with more and more powerful tools for predicting the functions and structures of proteins in order to guide their experimental work.
Second, we want to understand how transcriptional regulation, which represents the most important level of cellular regulation, is encoded in each gene's regulatory regions. We develop computational methods to analyse regulatory sequences and to detect regulatory motifs. We also want to predict transcription rates, using probabilistic modeling, statistical physics, and machine learning techniques. We collaborate extensively with experimental groups to elucidate the molecular processes regulating transcription initiation, elongation, mRNA processing, and chromatin states.
Homepage Department / Research Group
Selected Recent Publications
- Steinegger M, Soeding, J. (2017) Linclust: clustering billions of sequences per day on a single server. Under review. bioRxiv.
- Steinegger M, Söding J (2017) MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Nature Biotechnol., accepted. bioRxiv.
- Söding J (2017) Big-data approaches to protein structure prediction. Science (perspective), 355, 248-249.
- Siebert M, Söding J (2016) Markov models consistently outperform PWMs atpredicting regulatory motifs in nucleotide sequences. Nucleic Acids Res., 44, 6055-6069.
- Baejen C,# Andreani J,# Torkler P, Battaglia S, Schwalb B, Lidschreiber M, Maier KC, Boltendahl A, Rus P, Esslinger S, Söding J*, Cramer P* (2017) Genome-wide analysis of RNA polymerase II termination at protein-coding genes. Molecular Cell 66, 38-49.e6.
- Meier A, Söding J (2015) Automatic prediction of protein 3D Structures by probabilistic multi-template homology modeling. PLoS Comput. Biol., 11:e1004343.
- Siebert M, Söding J (2014) Universality of core promoter motifs? Nature (Brief Commun. Arising), 511, E11–E12.
- Schulz D#, Schwalb B#, Kiesel A, Baejen C, Torkler P, Gagneur J, Söding J*, Cramer P* (2013) Transcriptome surveillance by selective termination of noncoding RNA synthesis. Cell, 155, 1075-1087.
- Hartmann H, Guthohrlein EW, Siebert M, Luehr S, Södinh J (2013) P-value based regulatory motif discovery using positional weight matrices. Genome Res. 23, 181-194.