Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Schneider, Anja, Prof. Dr. med*

  • 2003 MD, Max-Planck-Units for Structural Molecular Biology, Hamburg & University of Hamburg Medical School, Training in Neurology at University Hospital in Tübingen and Training in Psychiatry at University Hospital Göttingen
  • 2004-2008 Research Fellow at Max Planck Institute for Experimental Medicine Göttingen
  • Since 2011 Consultant at the Psychiatry Department and head of the memory clinic
  • 2012-2014 DFG Heisenberg Fellowship
  • Since 2014 Professor for translational dementia research (W2) University Medical Center and German Center for Neurodegenerative Diseases

Major Research Interests

Our group studies basic and translational aspects of neurodegenerative dementia.

Our aims are:

1.To increase the understanding of the cellular mechanisms underlying the aggregation, toxicity and interneuronal propagation of alpha-synuclein and amyloid-beta. A special focus is the investigation of extracellular vesicles in disease propagation.
2.To develop new antecedent biomarkers which allow diagnosis and differential diagnosis of degenerative diseases prior to clinical disease onset.
3.The translation into therapeutical applications ensuing from primary cell cultures and mouse models leading to clinical studies.

Selected Recent Publications

  • Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation. Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A. Acta Neuropathol. 2015 Mar 17. [Epub ahead of print]
  • Neuron-to-neuron alpha-synuclein propagation is dependent on neuronal integrity. Ulusoy A, Musgrove RE, Rusconi R, Klinkenberg M, Helwig M, Schneider A, Di Monte DA. Acta Neuropathologica Comm., in press.
  • Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM. PLoS Biol. 2013 Jul;11(7):e1001604. doi: 10.1371/journal.pbio.1001604. Epub 2013 Jul 9.
  • Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease. Strauss K, Goebel C, Runz H, Möbius W, Weiss S, Feussner I, Simons M, Schneider A. J Biol Chem. 2010 Aug 20;285(34):26279-88. doi: 10.1074/jbc.M110.134775. Epub 2010 Jun 16.