Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Möbius, Wiebke, Dr.*

PhD in Biology

  • 1998 PhD, University of Bonn, Germany
  • 1999-2003 Postdoc with H. Geuze and J.W. Slot, Utrecht, The Netherlands
  • 2003-2004 Postdoc with G. Griffith and J. Krijnse-Locker, EMBL, University of Heidelberg, Germany
  • since 2004 Research Associate at the Department of Neurogenetics and Head of the Electron Microscopy Group at the Max Planck Institute for Experimental Medicine Göttingen, Germany

Major Research Interests

Cell Biology of the Myelinating Glia, Intracellular Transport, Myelin Biogenesis, Turnover and Maintenance

By using mouse genetics we investigate the cell biology and functions of the myelinating glia cells in the central as well as in the peripheral nervous system. The main research interest of the group is focusing on the mechanisms of myelin biogenesis, maintenance and turnover. By electron microscopy, one astonishing feature of myelin is the appearance as a solid and rather non-dynamic structure. Also, myelin proteins are known to turn over very slowly. To address this question we apply inducible knock-out strategies in the adult mouse, we can observe spatial and temporal changes in the myelin ultrastructure. To understand these and other myelin-related structural processes better, we developed protocols in electron microscopy to visualize structural features in normal and diseased state. We apply immunoelectron microscopy to study protein distribution at high spatial resolution as well as cryopreparation methods for optimized ultrastructural preservation of myelin morphology. With the help of a focused ion beam-scanning electron microscopy (FIB-SEM) and the application of serial block-face imaging we are able to add the third dimension to the ultrastructural analysis which is indispensable for the understanding of complex tissues or local connectivity.

Homepage Department/Research Group


Selected Recent Publications

  • Bartels M, Krenkel M, Cloetens P, Möbius W, Salditt T (2015) Myelinated mouse nerves studied by X-ray phase contrast zoom tomography. J Struct Biol. 2015 Dec;192(3):561-8
  • Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M (2014): Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell Jan 16;156(1-2):277-90
  • Nolting JF, Möbius W, Köster S (2014) Mechanics of Individual Keratin Bundles in Living Cells. Biophys J 107(11): 708-16
  • Schertel A, Snaidero N, Han H-M, Ruhwedel T, Laue M, Grabenbauer G, Möbius W (2013): Cryo FIB-SEM: volume imaging of cellular ultrastructure in native frozen specimens. J Struc Biol 2013 Nov;184(2):355-60
  • Viganò F, Möbius W, Götz M, Dimou L. (2013): Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat Neurosci. Oct;16(10):1370-2
  • Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, EdgarJ, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Moraes CT, Frahm J, Goebbels S, Nave K-A (2012): Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 485: 517-521
  • Möbius W, Cooper B, Kaufmann WA, Imig C, Ruhwedel T, Snaidero N, Saab AS, and Varoqueaux F (2010): Electron microscopy of the mouse central nervous system. Methods in Cell Biology Vol. 96:475-512