Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Behr, Rüdiger, (apl.) Prof. Dr.

Head of Platform Degenerative Diseases, German Primate Center


  • 1995 Diploma in Biology, Westfälische Wilhelms-Universität (WWU) Münster, Germany
  • 1998 PhD in Biology, Institute of Reproductive Medicine, WWU Münster, Germany
  • 1999 - 2005 Post Docs at the Institute of Reproductive Medicine of the WWU Münster; the University of Pennsylvania Medical School, Department of Genetics, Philadelphia, PA, USA; and the Institute of Anatomy, Developmental Biology, University of Essen, Germany
  • 2005 - 2008 Head of the Stem Cell Biology Junior Research Group, German Primate Center, Göttingen, Germany
  • 2008 - 2015 Head of Stem Cell Biology Unit, German Primate Center, Göttingen, Germany
  • Since 2016 Head of Platform Degenerative Diseases, German Primate Center, Göttingen, Germany




Major Research Interests

We are interested in the generation, characterization and genetic modification of primate pluripotent stem cells. We generated embryonic stem cells and induced pluripotent stem cells from the common marmoset monkey and compare these pluripotent stem cell types with natural monkey preimplantation embryos and pre-meiotic germ cells. In addition to this developmental aspect we use pluripotent stem cells in combination with gene editing technology to establish genetic disease models and to test, in collaboration with our partners, cell replacement therapies in pre-clinically relevant settings. Here we currently focus as a member of the Deutsches Zentrum für Herzkreislaufforschung (DZHK) on cardiovascular aspects.




Homepage Department / Research Group
http://www.dpz.eu/en/platforms/degenerative-diseases/about-us.html



Selected Recent Publications

  • Debowski K, Drummer C, Lentes J, Cors M, Dressel R, Lingner T, Salinas-Riester G, Fuchs S, Sasaki E, Behr R (2016) The transcriptomes of novel marmoset monkey embryonic stem cell lines reflect distinct genomic features. Sci Rep 6: 29122
  • Boroviak T, Loos R, Lombard P, Okahara J, Behr R, Sasaki E, Nichols J, Smith A, Bertone P (2015) Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis. Dev Cell 35:366-82
  • Wahab F, Drummer C, Behr R (2015) Marmosets. Curr Biol. 25:R780-2
  • Debowski K, Warthemann R, Lentes J, Salinas-Riester G, Dressel R, Langenstroth D, Gromoll J, Sasaki E, Behr R (2015) Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach. PLoS One. 2015 Mar 18;10(3):e0118424
  • Vogt EJ, Meglicki M, Hartung KI, Borsuk E, Behr R (2012) Importance of the pluripotency factor Lin28 in the mammalian nucleolus during early embryonic development. Development 139:4514-4523
  • Wahab F, Drummer C, Schlatt S, Behr R. (2016) Dynamic Regulation of Hypothalamic DMXL2, KISS1, and RFRP Expression During Postnatal Development in Non-Human Primates. Mol Neurobiol. [Epub ahead of print]
  • Müller T, Fleischmann G, Eildermann K, Mätz-Rensing K, Horn P, Sasaki E, Behr R (2009) A novel embryonic stem cell line derived from the common marmoset monkey (Callithrix jacchus) exhibiting germ cell-like characteristics. Hum Reprod 24 (6):1359-1372