Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Dr. Herre Jelger Risselada

Research associate at the Georg-August University Göttingen

  • 2009 PhD in Biophysical Chemistry (supervisor: Prof. Dr. S.J.Marrink)
  • 2009-2014 Postdoctoral fellow at the Max Planck Institute for Biophysical Chemistry Göttingen
  • 2014-present Groupleader at the Leibniz institute of Surface Modification Leipzig
  • 2016-present Independent research associate at the Georg-August University Göttingen

Major Research Interests

Our aim is to understand how proteins can act as nano machines to remodel lipid membranes and thereby drive fundamental processes for life such as fusion and fission. Which tricks do proteins use to overcome or alter the associated free energy barriers of these processes? Can one exploit these tricks to improve drug delivery systems or, alternatively, prevent viral infections? We tackle these questions by applying state-of-the-art molecular dynamics simulation techniques. In addition, we search for new ways to exploit Nature's inventions for the sake of material science (bio-inspired materials). For example, we computationally explore new types of bio-surfactants or try to design functional hybrid assemblies between bio-materials and solid surfaces or synthetic polymers.


Homepage Department / Research Group

Selected Recent Publications

  • A. Gladytz, B. Abel, H.J. Risselada*, "Gold-Induced Fibril Growth: The Mechanism of Surface-Facilitated Amyloid Aggregation", Angew. Chem. Int. Ed., 55:12242-46, 2016

  • H.J. Risselada*, G. Bubnis, H. Grubmüller, "Expansion of the fusion stalk and its implication for biological membrane fusion", Proc. Natl. Acad. Sci. USA., 111: 11043-110487, 2014

  • G. Van den Bogaart, K. Meyenberg K, H.J. Risselada, H. Amin, K.I. Willig, B.E. Hubrich, M. Dier, S.W. Hell, H. Grubmüller, U. Diederichsen, R. Jahn "Membrane protein sequestering by ionic protein-lipid Interactions", Nature 479: 552-55, 2011

  • H.J. Risselada*, S.J. Marrink, M. Müller, "Curvature-dependent elastic properties of liquid-ordered domains result in inverted domain sorting on uni-axially compressed vesicles", Phys. Rev. Lett. 106: 148102, 2011

  • H.J. Risselada, S.J. Marrink, "The molecular face of lipid rafts in model membranes", Proc. Natl. Acad. Sci. USA., 105:17367-17372, 2008