Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Brenig, Bertram, Prof. Dr.

Full Professor of Molecular Biology of Livestock

  • Director of the Institute of Veterinary Medicine
  • Dr. med. vet., University of Munich, Munich 1987

  • Major Research Interests

    We are interested in the structural and functional analysis of mammalian genes and genomes and are investigating the cause of different important genetic traits and defects in domestic animals.

    Currently we are working on the following projects:
    Molecular genetics of developmental defects of the eye (cataract, iris hypopigmentation) (cattle)
    Leg and feet disease (digital dermatitis, interdigital hyperplasia) (cattle)
    Early embryonal death (lethal haplotypes) (cattle)
    Male infertility (cattle)
    Developmental skeletal defects (Osteogenesis imperfecta, osteodystrophy) (cattle)
    Intervertebral disk disease (dog)
    Hemophilia A and B (dog)

    We are using genome wide association studies (high-throughput screening and genotyping, GWAS) and next generation sequencing (NGS) techniques for the identification of chromosomal regions that are linked to the traits or disorders. Fine mapping, positional cloning and candidate gene analysis are used for further elucidation.

    Homepage Department/Research Group


    Selected Recent Publications

    • Awasthi Mishra N, Drogemuller C, Jagannathan V, Keller I, Wuthrich D, Bruggmann R, Beck J, Schutz E, Brenig B, Demmel S, Moser S, Signer-Hasler H, Pienkowska-Schelling A, Schelling C, Sande M, Rongen R, Rieder S, Kelsh RN, Mercader N, Leeb T (2017) A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle. PLoS One 12: e0180170
    • Hollmann AK, Bleyer M, Tipold A, Nessler JN, Wemheuer WE, Schutz E, Brenig B (2017) A genome-wide association study reveals a locus for bilateral iridal hypopigmentation in Holstein Friesian cattle. BMC Genet 18: 30
    • Hollmann AK, Dammann I, Wemheuer WM, Wemheuer WE, Chilla A, Tipold A, Schulz-Schaeffer WJ, Beck J, Schutz E, Brenig B (2017) Morgagnian cataract resulting from a naturally occurring nonsense mutation elucidates a role of CPAMD8 in mammalian lens development. PLoS One 12: e0180665
    • Liu W, Beck J, Schmidt LC, Roolf C, Pews-Davtyan A, Rutgen BC, Hammer S, Willenbrock S, Sekora A, Rolfs A, Beller M, Brenig B, Nolte I, Junghanss C, Schutz E, Escobar HM (2016) Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells. Oncotarget 7: 35379-35389
    • Menzi F, Keller I, Reber I, Beck J, Brenig B, Schutz E, Leeb T, Drogemuller C (2016) Genomic amplification of the caprine EDNRA locus might lead to a dose dependent loss of pigmentation. Sci Rep 6: 28438