Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Brück, Wolfgang, Prof. Dr.

Professor of Neuropathology


  • 1986 MD Johannes Gutenberg University in Mainz, 1994 national boards in neuropathology
  • 1996-2002 Associate professorships for neuropathology at the University of Göttingen and the Charité in Berlin
  • Since 2002 full professor and director of the Department of Neuropathology, University of Göttingen



Major Research Interests

- Immunopathology of multiple sclerosis
- Brain-specific mechanisms of immune response in multiple sclerosis
- Axonal damage in inflammatory demyelination and mechanisms of remyelination
- Mechanisms and consequences of microglial activation


Homepage Department/ Research Group

http://www.neuropathologie.med.uni-goettingen.de



Selected Recent Publications


  • Kinzel S, Lehmann-Horn K, Torke S, Häusler D, Winkler A, Stadelmann C, Payne N, Feldmann L, Saiz A, Reindl M, Lalive PH, Bernard CC, Brück W, Weber MS. Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen. Acta Neuropathol, 132: 43-58, 2016
  • Jürgens T, Jafari M, Kreutzfeldt M, Bahn E, Brück W, Kerschensteiner M, Merkler D. Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. Brain, 139: 39-46, 2016
  • Pfeifenbring S, Nessler S, Wegner C, Stadelmann C, Brück W. Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice. J. Neuropathol. Exp. Neurol., 74: 756-66, 2015
  • Pfeifenbring S, Bunyan RF, Metz I, Röver C, Huppke P, Gärtner J, Lucchinetti CF, Brück W. Extensive acute axonal damage in pediatric multiple sclerosis lesions. Ann. Neurol., 77: 655-667, 2015
  • Metz I, Weigand SD, Popescu BF, Frischer JM, Parisi JE, Guo Y, Lassmann H, Brück W*, Lucchinetti CF*. Pathologic heterogeneity persists in early active multiple sclerosis lesions. Ann. Neurol., 75: 728-738, 2014
  • Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS. Therapeutic decisions in multiple sclerosis: moving beyond efficacy. JAMA Neurol., 70: 1315-1324, 2013
  • Singh S, Metz I, Amor S, van der Valk P, Stadelmann C, Brück W. Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons. Acta Neuropathol., 125: 595-608, 2013
  • Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, Wegner C. Reduced astrocytic NF-?B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol., 124:411-424, 2012
  • Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz I. Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann. Neurol., 72:385-394, 2012
  • Metz I, Radue EW, Oterino A, Kümpfel T, Wiendl H, Schippling S, Kuhle J, Sahraian MA, Gray F, Jakl V, Häusler D, Brück W. Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy. Acta Neuropathol., 123:235-245, 2012