Fischer, André, Prof. Dr.
2002: Dr. rer. nat.(PhD). University Goettingen/Max Planck Institute for Experimental Medicine, Germany
2003-2006: Postdoctoral Associate in the lab of Li-Huei Tsai; Harvard Medical School, Department of Pathology, Boston, USA; Picower Center for Learning and Memory, M.I.T, Cambridge, USA
Major Research Interests
Our group aims to understand the molecular mechanisms underlying learning and memory processes under physiological and pathological conditions. To this end we combine molecular, biochemical, pharmacological and behavioral approaches using mice as model organisms.
We are particularly interested to understand cognitive impairment associated with normal aging as well as the pathogenesis of mental and neurodegenerative diseases, such as anxiety disorders and Alzheimer’s disease.
Using animal models we deeply aim to identify therapeutic strategies that would help to reinstate neuroplasticity, learning behavior and the retrieval of lost long-term memories in patients suffering form such devastating diseases.
Homepage Department/Research Group
http://www.eni.gwdg.de/index.php?id=146
Publications
- Fischer A., Sananbenesi, F. Wang, X.Y., Dobbin, M,, Tsai L.H. Recovery of learning and memory is associated with chromatin remodeling. Nature, doi:10.1038/nature05772
- Fischer A., Radulovic M, Schrick C, Sananbenesi F, Godovac-Zimmermann J, Radulovic J (2006) Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior. Neurobiology of Learning and Memory 87:149-58
- Shu T., Tseng H.C., Zhou Y., Fischer A., Stern P., Coquelle F., Reiner O., Tsai L.H. (2006). Doublecortin-like Kinase Controls Neurogenesis by Regulating the Mitotic Spindle. Neuron, 49:25-39
- Fischer A., Sananbenesi F., Pang P.T., Lu B., Tsai L.H. (2005) Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus dependent memory. Neuron, 48: 825-83
- Park S.K., Nguyen M.D., Fischer A.[shared co-authorship], Affar E.B, Luke, M., Dieffenbach B., Shi, Y, Tsai L.H. (2005). Modulation of Dopamine Signaling by Prostate Apoptosis Response 4 via Direct Interaction with Dopamine D2 Receptor. Cell, 122:275-287
- Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J. (2004) Distinct roles of hippocampal protein synthesis and actin rearragnement in extinction of conditioned fear. J.Neurosci., 24:1962–1966
- Sananbenesi F., Fischer A., Schrick C., Spiess J., Radulovic J. (2003) Corticotropin-releasing factor receptor 2 induces mitogen-activated protein kinase signaling in the hippocampus: A possible link between stress and fear memory. J.Neurosci., 36:11436 –11443
- Fischer A., Sananbenesi F., Spiess J., Radulovic J. (2003) Cdk5 in the adult non-demented brain. Current drug targets CNS, 2, 61-72
- Fischer A., Sananbenesi F., Spiess J., Radulovic J. (2003) Cdk5: a novel role in learning and memory. NeuroSignals, 12, 200-208
- Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J. (2003) Regulation of contextual fear conditioning by baseline and inducible septo-hippocampal cyclin-dependent kinase 5. Neuropharmacology, 44, 1089-1099
- Sananbenesi F., Fischer A. [shared first-authorship], Schrick C., Spiess J., Radulovic J. (2002) Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1. Mol. Cell. Neurosci., 3, 463-476
- Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J. (2002) Cyclin-dependent kinase 5 is required for associative learning. J. Neurosci., 9, 3700-3007
- Radulovic J., Fischer A., Katerkamp U., Spiess J. (2000) Role of regional neurotransmitter receptors in corticotropin-releasing factor (CRF)-mediated modulation of fear conditioning. Neuropharmacology, 39, 707-710
- Sydow S., Flaccus A., Fischer A., Spiess J. (1999) The role of the fourth extracellular
domain of the rat corticotropin-releasing factor receptor type 1 in ligand binding. Eur. J. Biochem., 259, 55-62
- Radulovic J., Kammermeier, J., Fischer A., Spiess J. (1999) Lernen, Angst und Streß: Molekulare Verknüpfungen. In Körper, Seele, Trauma. Biologie, Klinik und Praxis. Ed. Streeck-Fischer A., Sachsse U., Özkan L. Vanderhoeck & Ruprecht, Göttingen, S.132-142
