Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften
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Fischer, André, Prof. Dr.

  • 2002: Dr. rer. nat.(PhD). University Goettingen/Max Planck Institute for Experimental Medicine, Germany

  • 2003-2006: Postdoctoral Associate in the lab of Li-Huei Tsai; Harvard Medical School, Department of Pathology, Boston, USA; Picower Center for Learning and Memory, M.I.T, Cambridge, USA

  • Major Research Interests

    Our group aims to understand the molecular mechanisms underlying learning and memory processes under physiological and pathological conditions. To this end we combine molecular, biochemical, pharmacological and behavioral approaches using mice as model organisms.
    We are particularly interested to understand cognitive impairment associated with normal aging as well as the pathogenesis of mental and neurodegenerative diseases, such as anxiety disorders and Alzheimer’s disease.
    Using animal models we deeply aim to identify therapeutic strategies that would help to reinstate neuroplasticity, learning behavior and the retrieval of lost long-term memories in patients suffering form such devastating diseases.

    Homepage Department/Research Group



    • Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A (2013) Insulin growth factor binding protein 7 is a novel target to treat dementia. Neurobiol Dis. 2013 Sep 25;62C:135-143

    • Sirko S, Behrendt G, Johansson P, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M (2013) The stem cell response of reactive glia differs in diverse injury paradigms revealing a key role of sonic hedgehog. Cell Stem Cell, in press

    • Kerimoglu C, Agis-Balboa R, Kranz A, Stilling R, Bahari-Javan S, Benito-Garagorri1 B, Halder R, Burkhardt S, Stewart AF, Fischer A (2013) Histone-methyltransferase MLL2 (kmt2b) is required for memory formation in mice. J. Neurosci, 33,8, 3452-3464

    • Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schlüter OM, Bradke F, Lu J, Fischer A (2013) Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease. EMBO Molecular Medicine, do10.1002/emmm.201201923. [Epub ahead of print]

    • Agis-Balboa RC, Pavelka S, Kerimoglu C, Fischer A (2012) Loss of HDAC5 impairs memory function: Implications for Alzheimer’s disease. Journal of Alzheimer's disease, 33(1)

    • Bahari-Javan S, Maddalena A, Kerimoglu C, Wittnam J, Held T, Bähr M, Burkhardt S, Delalle I, Kügler S, Fischer A, Sananbenesi F (2012) HDAC1 regulates fear extinction in mice. J. Neurosci, 32(15):5062-73

    • Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A (2011) microRNA-34c is a novel target to treat dementias. EMBO J. 2011 Sep 23;30(20):4299-308. doi: 10.1038/emboj.2011.327

    • Agis-Balboa RC, Arcos-Diaz D, Wittnam J, Govindarajan N, Blom K, Burkhardt S, Haladyniak U, Agbemenyah HY, Zovoilis A, Salinas-Riester G, Opitz L, Sananbenesi F, Fischer A (2011) A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. EMBO J. 2011 Aug 26;30(19):4071-83. doi: 10.1038/emboj.2011.293

    • Govindarajan N, Agis-Balboa RC, Walter J, Sananbenesi F, Fischer A (2011) Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J Alzheimers Dis. 2011;26(1):187-97

    • Kuczera T, Stilling RM, Hsia HE, Bahari-Javan S, Irniger S, Nasmyth K, Sananbenesi F, Fischer A (2010) The Anaphase Promoting Complex is required for memory function in mice. Learning&Memory, 18, 1:49-57

    • Brzózka MM, Fischer A, Falkai P, Havemann-Reinecke U (2010) Acute treatment with cannabinoid receptor agonist WIN55212,2 improves prepulse inhibition in psychosocially stressed mice. Behavioural Brain Research, 218, 2 :280-7. Epub 2010 Nov 9

    • Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhoffer M, Farinelli L, Chen W, Fischer A (2010) Altered histone H4 lysine 12 acetylation is associated with age-dependent memory impairment in mice. Science, 328; 753

    Fischer, André


    Prof. Dr. André Fischer
    Dep. For Psychiatry and Psychotherapy
    University Medical Center
    German Center for Neurodegenerative Diseases (DZNE)
    Grisebachstr. 5
    37077 Göttingen

    Tel.: +49-(0)551-39 10378
    Fax: +49-(0)551-39 9836
    e-mail: afische2@gwdg.de


    Molecular Physiology of the Brain (C

    Neurosciences (IMPRS)
    Systems Neuroscience
    Theoretical and Computational Neur