2003-2006: Postdoctoral Associate in the lab of Li-Huei Tsai; Harvard Medical School, Department of Pathology, Boston, USA; Picower Center for Learning and Memory, M.I.T, Cambridge, USA
2007-2011: Independent Group Leader at ENI
since 2011: W3 Professor at the Department for Psychiatry and Psychotherapy, University Medical Center Göttingen
since 2011: Speaker of the German Center for Neurodegenerative Diseases (DZNE) site Göttingen
Major Research Interests
The long-term goal of our research is to understand the cellular and molecular mechanisms underlying brain diseases and to develop neuroprotective and neurodegenerative therapeutic approaches. There is now accumulating evidence that on an individual level health or disease critically depends on the interaction between genes and environment. Epigenetic mechanisms such as histone-modification, DNA-methylation and non-coding RNA-mediated processes are key-regulators of gene-environment interactions. Importantly, such epigenetic mechanisms have recently been implicated with the pathogenesis of neurodegenerative and psychiatric diseases. Thus our current hypothesis is that deregualtion of genome-environment interactions, especially via epigenetic gene-expression, is a key feature of neurodegenerative diseases such as Alzheimer's disease. We combine studies in patient material, and mouse and cellular models sung a combination of behavioral, molecular, genetic and bioinformatic techniques to address these questions.