Dr. Herre Jelger Risselada

Research associate at the Georg-August University Göttingen

• 2009 PhD in Biophysical Chemistry (supervisor: Prof. Dr. S.J.Marrink)
• 2009-2014 Postdoctoral fellow at the Max Planck Institute for Biophysical Chemistry Göttingen
• 2014 – 2016 Groupleader at the Leibniz institute of Surface Modification Leipzig
• since 2016 Independent research associate at the Georg-August University Göttingen
• since 2018 NWO Vidi fellow at the University of Leiden, The Netherlands

Major Research Interests

Our aim is to understand how proteins can act as nano machines to remodel lipid membranes and thereby drive fundamental processes for life such as fusion and fission. Which tricks do proteins use to overcome or alter the associated free energy barriers of these processes? Can one exploit these tricks to improve drug delivery systems or, alternatively, prevent viral infections? We tackle these questions by applying state-of-the-art molecular dynamics simulation techniques. In addition, we search for new ways to exploit Nature's inventions for the sake of material science (bio-inspired materials). For example, we computationally explore new types of bio-surfactants or try to design functional hybrid assemblies between bio-materials and solid surfaces or synthetic polymers.







Homepage Department/Research Group

http://www.theorie.physik.uni-goettingen.de/~hrissel/



Selected Recent Publications

• D'Agostino M, Risselada HJ, Lürick A, Ungermann C, Mayer A (2017) A tethering complex drives the terminal stage of SNARE-dependent membrane fusion. Nature, 551: 634-638
• Gladytz A, Abel B, Risselada HJ (2016) Gold-Induced Fibril Growth: The Mechanism of Surface-Facilitated Amyloid Aggregation, Angew. Chem. Int. Ed., 55:12242-46
• Risselada HJ, Bubnis G, Grubmüller H (2014) Expansion of the fusion stalk and its implication for biological membrane fusion, Proc. Natl. Acad. Sci. USA., 111: 11043-110487
• Van den Bogaart G, Meyenberg K, Risselada HJ, Amin H, Willig KI, Hubrich BE, Dier M, Hell SW, Grubmüller H, Diederichsen U, Jahn R (2011) Membrane protein sequestering by ionic protein-lipid Interactions, Nature 479: 552-55
• Risselada HJJ, Marrink SJ, Müller M (2011) Curvature-dependent elastic properties of liquid-ordered domains result in inverted domain sorting on uni-axially compressed vesicles, Phys. Rev. Lett. 106: 148102
• Risselada HJ, Marrink SJ (2008) The molecular face of lipid rafts in model membranes, Proc. Natl. Acad. Sci. USA.,105:17367-17372