Matthew Grieshop


College / University

University of Wisconsin-Madison

Highest Degree

Bachelor of Science

Major Subjects

Biochemistry, Computer Science, Mathematics




Lab Experience

Solid-phase synthesis, Chromatography (TLC/HPLC/Size-Exclusion), Mass Spectrometry (MALDI-TOF/ESI), Mammalian cell culture, Microscopy, Agarose gels, RNA expression (RT-PCR/Northern Blotting/RNA-seq), ChIP-(qPCR/seq), Thio-U Pulse-Chase

Projects / Research

  • 02/2013 – 01/2016 Development of COSMIC (Crosslinking of Small Molecules to Isolate Chromatin) as a method to map genome occupancy of small molecules. (doi: 10.3791/53510)
  • 02/2013 – 10/2016 Mapping the genomic occupancy of synthetic genome readers across diverse chromatin states. (doi:10.1073/pnas.1604847113)
  • 02/2013 – 08/2017 Synthetic transcription elongation factors license transcription through repressive chromatin

Scholarships / Awards

2017 – 2018: Stipend by the International Max Planck Research School
2015: Hilldale Undergraduate Research Fellowship
2015: University of Wisconsin Biochemistry Undergraduate Summer Research Scholarship
2013 – 2016: University of Wisconsin Dean’s List
2013 – 2016: Wisconsin Academic Excellence Scholarship


During my scientific career to date, I have focused on developing small molecules in order to regulate specific checkpoints in transcription at target genomic loci. My research has required techniques in synthetic chemistry, cell biology, and bioinformatics. One topic of particular interest to me is protein engineering. I would like to gain practical experience with various biochemical and bioinformatics techniques such as directed evolution or the Rosetta package. In the molecular biology program, I hope to further develop my scientific interests while becoming acquainted with a broader range of topics.