Project (Eugenio Fornasiero)
Unlocking the secrets of protein turnover in the mammalian brain
Description:
The equilibrium between protein production and degradation, as well as the control of protein lifespans, plays a central role in the majority of biological processes. Our research group is dedicated to devising methods and analytical workflows to quantify and interpret changes in protein lifespans within mammalian tissues. Using these techniques, we aim to unveil the underlying molecular mechanisms and fundamental principles governing protein turnover, with a particular emphasis on the brain in relation to physiology, aging, and neurodegeneration.
We are committed to advancing and refining novel approaches for investigating protein production and degradation, elucidating their interplay with mRNA stability and translation efficiency, and clarifying the fundamental principles underpinning homeostatic proteome regulation. These ongoing endeavors require inquisitive young scientists with a background in computational biology, physics, mathematics, or informatics, who will actively contribute to the refinement and enhancement of our analytical tools. Specific projects will be developed in coordination with candidates who express interest in these research areas.
Homepage Research Group
https://www.fornasierolab.uni-goettingen.de
For more information see for instance:
- A mass spectrometry workflow for measuring protein turnover rates in vivo.
Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF.
Nat Protoc. 2019 Dec;14(12):3333-3365. doi: 10.1038/s41596-019-0222-y. Epub 2019 Nov 4.
PMID: 31685960
- Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration.
Kluever V, Russo B, Mandad S, Kumar NH, Alevra M, Ori A, Rizzoli SO, Urlaub H, Schneider A, Fornasiero EF.
Sci Adv. 2022 May 20;8(20):eabn4437. doi: 10.1126/sciadv.abn4437. Epub 2022 May 20.
PMID: 35594347
- Determining and interpreting protein lifetimes in mammalian tissues.
Fornasiero EF, Savas JN.
Trends Biochem Sci. 2023 Feb;48(2):106-118. doi: 10.1016/j.tibs.2022.08.011. Epub 2022 Sep 23.
PMID: 36163144 Free article. Review.