Project (Hannelore Ehrenreich)



PhD Position for Genetics of Neuropsychiatric Disease

Highly qualified candidates with a clear commitment to basic and interdisciplinary genetic research on brain diseases are invited to apply. The successful applicant will work from bench to bedside in a multidisciplinary and international team and receive support by technical personnel. Applicants should hold a master/diploma in genetics, bioinformatics or related disciplines. They should be fluent in English, have a strong interest in promoting their scientific career in genetics of neuropsychiatric diseases. We are seeking highly enthusiastic and ambitious individuals with particular interest in translational and clinical neuroscience. Specifically, the applicant would utilize the presently world-wide largest phenotypical database (GRAS data collection) on schizophrenia and autism for novel approaches to phenotype-based genetic association studies (PGAS). Dependent on the outcome of these approaches, i.e. the identified genotype constellations, further work may involve expression analyses (e.g. DropSeq, qPCR, protein, IHC, FACS) or clinical follow-up studies (e.g. neuropsychology, MRI).




Homepage Research Group



http://www.em.mpg.de




For more information see for instance:

Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA (2018): OTTO: A new strategy to extract mental disease-relevant combinations of GWAS hits from individuals; Mol Psychiatry, doi: 10.1038/mp.2016.208


Mitjans M, Seidel J, Begemann M, Bockhop F, Moya-Higueras J, Bansal V, Wesolowski J, Seelbach A, Ibáñez MI, Kovacevic F, Duvar O, Fañanás L, Wolf HU, Ortet G, Zwanzger P, Klein V, Lange I, Tänzer A, Dudeck M, Penke L, van Elst LT, Bittner RA, Schmidmeier R, Freese R, Müller-Isberner R, Wiltfang J, Bliesener T, Bonn S, Poustka L, Müller JL, Arias B, Ehrenreich H. (2018) Violent aggression predicted by multiple pre-adult environmental hits. Mol Psychiatry doi: 10.1038/s41380-018-0043-3. [Epub ahead of print]


Bansal V, Mitjans M, Burik CAP, Linnér RK, Okbay A, Rietveld CA, Begemann M, Bonn S, Ripke S, de Vlaming R, Nivard MG, Ehrenreich H, Koellinger PD (2018) Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. Nat Commun. Aug 6;9(1):3078. doi: 10.1038/s41467-018-05510-z.


Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA (2018) Microglia ablation alleviates myelin-associated catatonic signs in mice, J Clin Invest, 128(2):734-745. doi: 10.1172/JCI 97032. Epub 2017 Dec 18.


Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H (2018) Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model; Mol Psychiatry, doi: 10.1038/s41380-017-0011-3. [Epub ahead of print]


Castillo-Gomez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann W-H, Bertrand D, Hollmann M, Ehrenreich H (2017): All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry, doi: 10.1038/mp.2016.125


Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H (2015): Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. EMBO Mol Med 7(12):1565-79
Stepniak B, Papiol S, Hammer C, Ramin A, Everts S, Hennig L, Begemann M, Ehrenreich H (2014): Accumulated environmental risk determining age at schizophrenia onset, Lancet Psychiatry 1(6):444-53. doi: 10.1016/S2215-0366(14)70379-7.


Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014): Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510):421-7
Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H (2013): Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 10: 1143-49