• Ravindran E., Arashiki N., Becker L.L., Takizawa K., Lévy J., Rambaud T., Makridis K.L., Goshima Y., Li N., Vreeburg M., Demeer B., Dickmanns A. , Stegmann A.P.A., Hu H., Nakamura F., Kaindl A.M. (2022). Monoallelic CRMP1 gene variants cause neurodevelopmental disorder. Elife. 2022 Dec 13;11:e80793. doi: 10.7554/eLife.80793. Online ahead of print. PMID: 36511780. [Abstract]

  • Heidemann, JL., Neumann, P., Krüger, L., Wicke, D., Vinhoven, L., Linden, A,, Dickmanns, A., Stülke, J., Urlaub, H. and Ficner, R. (2022) Structural basis for c-di-AMP-dependent regulation of the bacterial stringent response by receptor protein DarB. J Biol Chem. Jun 14:102144 [Abstract] PDB: [6YJ7] [6YJ8] [6YJ9] [6YJA]

  • Giansanti C, Manzini V, Dickmanns A, Dickmanns A, Palumbieri MD, Sanchi A, Kienle SM, Rieth S, Scheffner M, Lopes M, Dobbelstein M. (2022). MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression. Cell Rep. 2022 May 31;39(9):110879. doi: 10.1016/j.celrep.2022.110879. [Abstract]


  • Perera, RP., Shaikhqasem, A., Rostam, N., Dickmanns, A., Ficner, R., Tittmann, K. and Dosch, R. (2021) Bucky Ball Is a Novel Zebrafish Vasa ATPase Activator. Biomolecules. Oct 13;11(10):1507. [Abstract]

  • Ravindran, E. , Jühlen, R., Vieira-Vieira, C.H., Ha, T., Salzberg, Y., Fichtman, B., Luise-Becker, L., Martins, N., Picker-Minh, S., Bessa, P., Arts, P., Jackson, M.R., Taranath , A., Kamien , B., Barnett, C., Li, N., Tarabykin, N., Stoltenburg-Didinger, D., Harel, A., Selbach, M., Dickmanns, A., Fahrenkrog, B., Hu, H., Scott, H., and Kaindl, A.M. (2021). Expanding the phenotype of NUP85 mutations beyond nephrotic syndrome to primary autosomal recessive microcephaly and Seckel syndrome spectrum disorders. Hum Mol Genet. 2021 Jun 25; ddab160. doi: 10.1093/hmg/ddab160. Online ahead of print. [Abstract]

  • Krüger, L., Herzberg, C., Wicke, D., Bähre, H., Heidemann, JL., Dickmanns, A., Schmitt, K., Ficner, R. and Stülke, J. (2021) A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis. Nat Commun. Feb 22;12(1):1210. doi: 10.1038/s41467-021-21306-0. [Abstract]


  • Shaikhqasem, A., Dickmanns, A., Neumann, P. and Ficner R. (2020) Characterization of inhibition reveals distinctive properties for human and Saccharomyces cerevisiae CRM1. J Med Chem. 2020 Jun 25. doi: 10.1021/acs.jmedchem.0c00143. Online ahead of print. PMID: 32585100 [ Abstract] PDB:[6TVO]


  • Heidemann, JL., Neumann, P., Dickmanns, A. and Ficner.R. (2019) Crystal structures of the c-di-AMP synthesizing enzyme CdaA. J Biol Chem. May 22. pii: jbc.RA119.009246. doi: 10.1074/jbc.RA119.009246. [Epub ahead of print][Abstract] PDB: [6HVL] [6HVM] [6HVN]


  • Bonnin, E., Cabochette, P., Filosa, A., Jühlen, R., Komatsuzaki, S., Hezwani, M., Dickmanns, A., Martinelli, V., Vermeersch, M., Supply, L., Martins, N., Pirenne, L., Ravenscroft, G., Lombard, M., Port, S., Spillner, C., Janssens, S., Roets, E., Van Dorpe, J., Lammens, M., Kehlenbach, RH., Ficner, R., Laing, NG., Hoffmann, K., Vanhollebeke, B. and Fahrenkrog, B. (2018) Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. PLoS Genet. Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845. [Epub ahead of print] [Abstract]

  • Neumann, P., Dickmanns, A.. and Ficner R. (2018) Validating Resolution Revolution. Structure. Mar 19. pii: S0969-2126(18)30084-4. doi: 10.1016/j.str.2018.03.004. [Epub ahead of print] [Abstract]

  • Dickmanns, A. and Ficner R. (2018). X-Ray Structure Analysis, Chapter 22 in “Bioanalytics: Analytical Methods and Concepts in Biochemistry and Molecular Biology” ; Editors: F. Lottspeich und J.W. Engels; Wiley, 1st edition; ISBN: 978-3-527-33919-8

  • Dickmanns, A., Zschiedrich, CP., Arens, J., Parfentev, I., Gundlach, J., Hofele, R., Neumann, P., Urlaub, H., Görke, B., Ficner, R. and Stülke J. (2018). Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis. J Biol Chem. 2018 Mar 7. pii: jbc.RA117.001289. doi: 10.1074/jbc.RA117.001289. [Epub ahead of print] [Abstract]

    • 2017

      • Ficner, R., Dickmanns, A., Neumann, P. (2017). Studying Structure and Function of Spliceosomal Helicases. Methods, Aug 1; 125:63-69 [Abstract]


      • Tauchert, MJ., Hémonnot, C., Neumann, P., Köster, S., Ficner, R. and Dickmanns A. (2016). Impact of the crystallization condition on importin-? conformation. Acta Crystallogr D Struct Biol. 72:705-717. [Abstract] PDB: [4XRI] [4XRK]


      • Monecke, T. , Dickmanns, A. , Weiss, MS., Port, SA., Kehlenbach, RH. and Ficner R. (2015). Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex. Acta Crystallogr F Struct Biol Commun. Dec 1;71(Pt 12):1481-1487. [Abstract] PDB: [5DIS]

      • Dickmanns, A. , Kehlenbach, RH. and Fahrenkrog B. (2015). Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease. Int Rev Cell Mol Biol. 320:171-233. [Abstract]

      • Port, SA., Monecke, T., Dickmanns, A. , Spillner, C., Hofele, R., Urlaub, H., Ficner, R. and Kehlenbach, RH. (2015). Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep. Oct 27; 13(4): 690 - 702 [Abstract]PDB: [5DIS]

      • Dickmanns, A. , Monecke, T. and Ficner, R. (2015). Structural Basis of Targeting the Exportin CRM1 in Cancer. Cells, 4(3), 538 - 568 Review. [Abstract]

      • Halder K., Dölker N., Van Q., Gregor I., Dickmanns A., Baade I., Kehlenbach RH., Ficner R., Enderlein J., Grubmüller H. and Neumann H.(2015). MD Simulations and FRET Reveal an Environment-Sensitive Conformational Plasticity of Importin-ß. Biophys J. 2015 Jul 21;109(2):277-86.[Abstract]

      • Commichau,FM., Dickmanns, A., Gundlach, J., Ficner, R. and Stülke, J. (2015). A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.Mol Microbiol. 2015 Jul;97(2):189-204. [Abstract]

      • Rosenberg, J., Dickmanns,A., Neumann, P., Gunka, K., Arens, J., Kaever, V., Stülke, J., Ficner, R., and Commichau, F.M.(2015). Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. J. Biol. Chem., Mar 6;290(10):6596-606. [Abstract]; PDB: [4RV7]

      • Gundlach, J., Dickmanns A., Schröder-Tittmann K., Neumann P., Kaesler J., Kampf J., Herzberg C., Hammer E., Schwede F., Kaever V., Tittmann K., Stülke J., and Ficner R. (2015). Identification, characterization and structure analysis of the c-di-AMP binding PII-like signal transduction protein DarA. J. Biol. Chem., Jan 30; 290 (5): 3069-80 [Abstract]; PDB: [4RLE]


      • Monecke, T., Dickmanns, A. and Ficner R. (2014) Allosteric control of the exportin CRM1 unraveled by crystal structure analysis. FEBS J., 2014 Sep;281(18):4179-94. [Abstract]


      • Ahmed, Y.L., Gerke, J., Park, H.-S., Bayram, Ö., Neumann, P., Min Ni, M., Dickmanns, A. , Kim, S.C. , Yu, J.-H., Braus, G.H. and Ficner, R. (2013). The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-kB. PlosBiol., 11(12): e1001750 [Abstract] [Article] ; PDB: [4N6Q] [4N6R]

      • Dölker, N., Blanchet, C.E., Voß, B., Haselbach, D., Kappel , C., Monecke, T., Svergun, D.I., Stark, H., Ficner, R., Zachariae, U., Grubmüller, H. and Dickmanns, A. (2013). Structural determinants and mechanism of mammalian CRM1 allostery. Structure, 21:1350-1360. [Abstract]; EMDB: [EMD-2274] [EMD-5564]

      • Monecke, T., Haselbach, D., Voß, B., Russek, A., Neumann, P., Thomson, E., Hurt, E., Zachariae, U., Stark, H., Grubmüller, H., Dickmanns, A *. and Ficner, R. (2013). Structural basis for cooperativity of CRM1 export complex formation. PNAS USA. 110, 960-965. [Abstract]; [Publication]; PDB: [4FGV], [4HZK], EMDB: [EMD-2110], [EMD-2111]


      • Neumann, P., Brodhun, F., Sauer, K., Herrfurth, C., Hamberg, M., Brinkmann, J., Scholz, J., Dickmanns, A., Feussner, I. and Ficner R. (2012). Crystal structures of Physcomitrella patens AOC1 and 2: Insights into the enzyme mechanism and differences in substrate specificity. Plant Physiol. 160, 1251-1266. [Abstract]; PDB: [4H69], [4H6A], [4H6B], [4H6C]

      • Ficner, R. und Dickmanns, A. (2012). Röntgenstrukturanalyse, Kapitel 22 in „Bioanalytik“; Hrsg: F. Lottspeich und J.W. Engels; Spektrum-Akademischer Verlag, 3. Aufl.; ISBN: 3827429420, EAN: 9783827429421


      • Dickmanns A., Damerow S., Neumann P., Schulz E.-C., Lamerz A.-C., Routier H. F., Ficner R. (2011). Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major.
        J.Mol.Biol., 2011, Jan 14;405(2):461-78.
        [Abstract]; PDB:[3OGZ][3OH0][3OH1][3OH2][3OH3][3OH4]


      • Lakomek, K., Dickmanns, A., Ciirdaeva, E., Schomacher, L. and Ficner, R. (2010). ≈ Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA J Mol Biol. 2010 Jun 18;399(4):604-17. [Abstract]; PDB:[3G00][3G0A][3G0R][3G1K][3G2C][3G2D][3G38][3G3C][3G3Y][3G4T][3G8V][3G91][3FZI][3GA6]

      • Kühn-Hölsken, E., Lenz, C., Dickmanns, A., Hsiao, H.-H., Richter, F.M., Kastner, B., Ficner, R., and Urlaub, H. (2010). Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry Nucleic Acids Res. 2010 Sep 1;38(16):5581-93. [Abstract]

      • Schulz, E.-C., Schwarzer, D, Frank, M., Stummeyer, K., Mühlenhoff, M., Dickmanns, A., Gerardy-Schahn, R., and Ficner, R. (2010). Structural basis for recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein endoNF. J. Mol. Biol., 937, 341-51[Abstract]; PDB:[3GVJ][3GVK][3GVL]

      • Schulz, E.-C., Dickmanns, A., Urlaub, H., Schmitt, A., Mühlenhoff, M., Stummeyer, K., Schwarzer, D., Gerardy-Schahn, R., and Ficner, R. (2010). Crystal structure of a novel intramolecular chaperone mediating triple ß-helix folding. Nature Struct. Mol. Biol., 17, 210-5, [Abstract]; PDB:[3GUD][3GW6]


      • Monecke, T., Dickmanns, A. and Ficner, R. (2009). Erkennung des RNA-5`-caps durch Proteine. Biospektrum 07.09, 720-725.

      • Lakomek, K., Dickmanns, A. , Kettwig, M., Urlaub, H., Ficner, R., and Luebke, T. (2009). Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography. BMC Struct Biol.,9, 56. [Abstract]; PDB:[3FGR][3FGT][3FGW]

      • Oschlies, M., Dickmanns, A. , Haselhorst, T., Schaper, W., Stummeyer, K., Tiralongo, J., Weinhold, B., Gerardy-Schahn, R., von Itzstein, M., Ficner, R., and Münster-Kühnel, A.K. (2009). A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme. J Mol Biol. 393:83-97 [Abstract]; PDB:[3EWI]

      • Dickmanns, A. (2009). Import and Export of UsnRNPs. Nuclear Transport; Edited by Ralph H. Kehlenbach, Landes Bioscience

      • Monecke, T., Dickmanns, A. , and Ficner, R. (2009). Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res. 37, 3865-3877. [Abstract]; PDB:[3GDH]

      • Monecke, T., Güttler, T., Neumann, P., Dickmanns, A. , Görlich, D., and Ficner, R. (2009). Crystal structure of the nuclear export receptor CRM1 in complex with snurportin1 and RanGTP. Science 324, 1087-1091. [Abstract]; PDB:[3GJX]

      • Monecke,T., Dickmanns, A. , Strasser A., and Ficner R. (2009). Structure Analysis of the conserved Methyltransferase Domain of Human Trimethylguanosine Synthase TGS1. Acta Cryst. D65, 332-338. [Abstract]; PDB:[3EGI]

      • Lakomek, K., Dickmanns, A. , Müller, U., Kollmann, K., Deuschl, F., Berndt, A., Lübke, T., and Ficner, R. (2009). De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse. Acta Crystallogr. D 65, 220-8. [Abstract]; PDB:[3FBXI]

      • Padmanabhan, N., Fichtner, L., Dickmanns, A. , Ficner, R., Schulz, J.B., and Braus, G. (2009). The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival under Heat Stress. Mol.Cell. Biol., 20, 68-77. [Abstract]


      • Keyser, B., Mühlhausen, C., Dickmanns, A., Christensen, E., Muschol, N., Ullrich, K. and Braulke, T. (2008). Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH). Hum Mol Genet. 17:3854-63. [Abstract]

      • Monecke, T., Schell, S., Dickmanns, A., and Ficner R. (2008). Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m7G-cap binding mode. J. Mol. Biol. 382, 827-34. [Abstract]; PDB:[3CTR]

      • Schäfer, S., Saunders, L., Eliseeva, E., Velena, A., Jung, M., Schwienhorst, A., Strasser, A., Dickmanns, A., Ficner, R., Schlimme, S., Sippl, W., Verdin, E., and Jung, M. (2008). Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg. Med. Chem. 16, 2011-2033. [Abstract]; PDB:[2VGC]


      • Wohlwend, D., Strasser, A., Dickmanns, A., and Ficner R. (2007). Structural Basis for RanGTP Independent Entry of Spliceosomal U snRNPs into the Nucleus.J. Mol. Biol. 374, 1129-1138. [Abstract]; PDB:[2QNA]

      • Wohlwend, D., Strasser, A., Dickmanns, A., Doenecke, D. and Ficner R. (2007). Thermodynamic analysis of H1 nuclear import: receptor tuning of importinbeta/importin7. J. Biol. Chem. 282, 10707-10719. [Abstract]


      • Dickmanns, A., Ballschmitter, M., Liebl, W. and Ficner, R. (2006). Crystal structure of the novel α-amylase AmyC from Thermotoga maritima. Acta Crystallogr. D62, 262-270. [Abstract]; PDB:[2B5D]


      • Nielsen, T.K., Hildmann, C., Dickmanns, A., Schwienhorst, A. and Ficner, R. (2005). Crystal structure of a bacterial class 2 histone deacetylase. J. Mol. Biol. 354, 107-120. [Abstract]; PDB:[1ZZ0][1ZZ1][1ZZ3]

      • Strasser, A., Dickmanns, A., Lührmann, R. and Ficner, R. (2005). Structural basis for m3G-cap mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J. 24, 2235-2243. [Abstract]; PDB:[1XK5]

      • Roeser, D.,Dickmanns, A., Gasow, K. and Rudolph, M.G. (2005). De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data. Acta Crystallogr D61:1057-66 [Abstract]; PDB:[xxxx]

      • Dierks, T., Dickmanns, A., Preusser-Kunze, A., Schmidt, B., Mariappan, M., von Figura, K., Ficner, R. and Rudolph, M.G. (2005). Molecular basis for multiple sulfatase deficiency and catalytic mechanism for formylglycine generation of the human formylglycine generating enzyme.Cell 121, 541-552. [Abstract]; PDB:[1Y1E][1Y1F][1Y1G][1Y1H][1Y1I][1Y1J]

      • Dickmanns, A., Schmidt, B., Rudolph, M.G., Mariappan, M., Dierks, T., von Figura, K. and Ficner, R. (2005). Crystal structure of human pFGE, the paralogue of the Ca-formylglycine generating enzyme. J. Biol. Chem. 280, 15180-15187. [Abstract]; PDB:[1Y4J]

      • Dickmanns, A. and Ficner, R. (2005). Role of the 5’-cap in the biogenesis of spliceosomal snRNPs.
        Topics in Current Genetics 12, 179-204.

      • Stummeyer, K., Dickmanns, A., Mühlenhoff, M., Gerardy-Schahn, R. and Ficner, R. (2005). Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F. Nature Struct. Mol. Biol. 12, 90-96. [Abstract]; PDB:[1V0E][1V0F]]


      • Strasser, A., Dickmanns, A., Schmidt, U., Penka, E., Urlaub, H., Sekine, R., Lührmann, R. and Ficner, R. (2004). Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snuportin1. Acta Crystallogr. D60, 1628-1631. [Abstract]


      • Rudolph, M.G., Kraus, I., Dickmanns, A., Eickmann, M., Garten, W. and Ficner, R. (2003). Crystal Structure of the Borna Disease Virus Nucleoprotein. Structure, 11: 1219-1226. [Abstract]; PDB:[1N93][1PP1]


      • Watkins, N.J., Dickmanns, A.and Lührmann, R. (2002) Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.
        Mol Cell Biol.; 22(23):8342-52.

      • Huber, J.,Dickmanns, A.and Lührmann, R. (2002) The importin-beta binding domain of Snurportin 1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J Cell Biol.; 156(3):467-79.[Abstract]


      • Kues, T., Dickmanns, A., Lührmann, R., Peters, R. and Kubitscheck U. (2001). High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking. PNAS U S A. 98(21):12021-6. [Abstract]


      • Müller, D., Thieke, K., Bürgin. A., Dickmanns, A. , and Eilers, M. (2000). Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60. EMBO J. 19(10):2168-80.[Abstract]


      • Kehlenbach, R.H., Dickmanns, A., Kehlenbach, A., Guan, T. and Gerace L. (1999). A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.
        J Cell Biol.,145:645-57.


      • Kehlenbach, R.H., Dickmanns, A. and Gerace L. (1998). Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro. J Cell Biol.;141(4):863-74. [Abstract]


      • Dickmanns, A., Bischoff, F.R., Marshallsay, C., Lührmann, R., Ponstingl, H., and Fanning, E. (1996). The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N. J Cell Sci.,109:1449-57. [Abstract]

      • Marshallsay C, Dickmanns, A., Bischoff FR, Ponstingl H, Fanning E, Lührmann R. (1996). In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1. Nucleic Acids Res.; 24(10):1829-36. Erratum in: Nucleic Acids Res.; 24(13):2626. [Abstract]


      • Pantel, K., Dickmanns, A., Zippelius, A., Klein, C., Shi, J., Hoechtlen-Vollmar, W., Schlimok, G., Weckermann, D., Oberneder, R., Fanning, E., et al..(1995). Establishment of micrometastatic carcinoma cell lines: a novel source of tumor cell vaccines. J Natl Cancer Inst.; 87(15):1162-8.[Abstract]


      • Hermeking, H., Wolf, D.A., Kohlhuber, F., Dickmanns, A., Billaud, M., Fanning, E. and Eick, D. (1994). Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts. PNAS USA., 91:10412-6.[Abstract]

      • Dickmanns, A., Zeitvogel, A., Simmersbach, F., Weber, R., Arthur, A.K., Dehde, S., Wildeman, A.G. and Fanning, E. (1994). The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen. J Virol.; 68(9):5496-508.[Abstract]


      • van Zee, K., Dickmanns, A., Fischer, U., Lührmann, R. and Fanning, E. (1993) A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA. J Cell Biol., 121(2):229-40. [Abstract]


      • Dobbelstein, M., Arthur, A.K., Dehde, S., van Zee, K., Dickmanns, A. and Fanning, E. (1992). Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells. Oncogene.; 7(5):837-47. [Abstract]