Department for Molecular Structural Biology


Dr. Piotr Neumann



My CV




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Publications:



2010


  • Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J. (2010).Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus..J Mol Biol. 2010 in press.[Abstract]; PDB:[xxxI][xxx]

  • Maestre-Martínez M, Haupt K, Edlich F, Neumann P, Parthier C, Stubbs MT, Fischer G, Lücke C. (2010). A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.J Mol Recognit., in press.[Abstract]; PDB:[xxxI][xxx]

  • Schulz, E.-C., Neumann, P., Gerardy-Schahn, R., Sheldrick, G.M., and Ficner, R. (2010).Crystal structure analysis of endosialidaseNF at 0.98 Å resolution.Acta Crystallogr. D, in press.[Abstract]; PDB:[xxxI][xxx]



2009


  • Weininger U., Zeeb M., Neumann P., Löw C., Stubbs MT, Lipps G, Balbach J. (2009) Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus. Biochemistry. 2009 Oct 27;48(42):10030-7.[Abstract]; PDB:[3FT7 ]; PDB:[2K9I]

  • Monecke, T., Güttler, T., Neumann, P., Dickmanns, A., Görlich, D., and Ficner, R. (2009). Crystal structure of the nuclear export receptor CRM1 in complex with snurportin1 and RanGTP.Science 324, 1087-1091. [Abstract]; PDB:[3GJX]

  • Neumann P., Lieber D, Meyer S, Dautel P, Kerth A, Kraus I, Garten W, Stubbs MT. (2009) Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3710-5. Epub 2009 Feb 23.[Abstract]; PDB:[3F1J ]



2008


  • Barak N.N*., Neumann P.*, Sevvana M., Schutkowski M., Naumann K., Malesevič M., Fischer G., Stubbs M.T., Ferrari D.M. (2008) Structural and Functional Studies on mammalian Erp29. J Mol Biol. 2009 Feb 6;385(5):1630-42. Epub 2008 Dec 3. [Abstract]; PDB:[2QC7 ]

  • Neumann P.*, Weidner A.*, Pech A., Stubbs M.T., Tittmann K. (2008) Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli. PNAS. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17390-5. Epub 2008 Nov 6. [Abstract]; PDB:[3EY9]; [3EYA]

  • Hoffmann A., Funkner A., Neumann P., Juhnke S., Walther M., Schierhorn A., Weininger U., Balbach J., Reuter J., Stubbs M.T. (2008) Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms., kursiv>J. Biol. Chem. 2008 Nov 21;283(47):32598-609. Epub 2008 Sep 12.[Abstract]; PDB:[3E07]

  • Yonus H.*, Neumann P*., Zimmermann S., May J.J., Marahiel M. and Stubbs M.T. (2008) Crystal structure of DLTA: implications for the reaction mechanism of non-ribosomal peptide synthetase (NRPS) adenylation domains. J. Biol. Chem. 2008 Nov 21;283(47):32484-91. Epub 2008 Sep 10. [Abstract]; PDB:[3E7W]; [3E7X]

  • Hoffmann A., Neumann P., Schierhorn A. and Stubbs M.T. (200) Crystallisation of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster. Acta Cryst. (2008). F64, 707-710[Abstract]

  • Kopycki J.G., Rauh D., Chumanevich A.A., Neumann P., Vogt T., Stubbs M.T. (2008) Biochemical and structural analysis of substrate promiscuity in plant Mg2+-dependent O-methyltransferases. J. Mol. Biol. 2008 Apr 18;378(1):154-64. Epub 2008 Feb 20[Abstract]; PDB:[3CBG]

  • Kozakiewicz A., Neumann P., Banach M., Komoszyński M., Wojtczak A. (2008) Modeling studies of potato nucleoside triphosphate diphosphohydrolase NTPDase1: an insight into the catalytic mechanism. Acta Biochim Pol. 2008;55(1):141-50. Epub 2008 Mar 11[Abstract]

  • Weidner A., Neumann P., Wille G., Stubbs M.T., Tittmann K. (2008) Crystallization and preliminary X-ray diffraction analysis of full-length and proteolytically activated pyruvate oxidase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Mar 1;64(Pt 3):179-81. Epub 2008 Feb 23.[Abstract]

  • Löw C., Weininger U., Neumann P., Klepsch M., Lilie H., Stubbs M.T., Balbach J. (2008) Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3779-84. Epub 2008 Feb 27.[Abstract]; PDB:[2RFM]



2007


  • Parthier C., Kleinschmidt M., Neumann P., Rudolph R., Manhart S., Schlenzig D., Fanghänel J., Rahfeld J.U., Demuth H.U., Stubbs M.T. (2007) Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35): 13942-7. Epub 2007 Aug 21[Abstract]; PDB:[2QKH]



2006



  • Stec E., Witkowska-Zimny M., Hryniewicz M.M., Neumann P., Wilkinson A.J., Brzozowski A.M., Verma C.S., Zaim J., Wysocki S., Bujacz G.D. (2006) Structural basis of the sulphate starvation response in E. coli: crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator. J Mol Biol. 2006 Dec 1;364(3):309-22. Epub 2006 Jun 30.[Abstract]; PDB:[2FYI]



2005



  • Neumann P., Cody V., Wojtczak A. (2005) Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution. Acta Crystallogr D Biol Crystallogr. 2005 Oct;1313-9. Epub 2005, Sep 28. [Abstract]; PDB:[1Z7JI]



2002


  • Zaidlewicz M., Sokół W., Wojtczak A., Neumann P. & Nissinen M. (2002). Synthesis with organoboranes. 14. Enolization - aldolization of conjugated cyclohexenones via dienoloborinates. Tetrahedron Lett. 43, 3525-3528.



2001



  • Neumann P., Cody V. & Wojtczak A. (2001). Structural basis of negative cooperativity in transthyretin. Acta Biochim. Polonica, 48, 867-875.[Abstract]

  • Wojtczak A., Neumann P. & Cody V. (2001). Structure of a new polymorphic monoclinic form of human transthyretin at 3 Å resolution reveals a mixed complex between unliganded and T4-bound tetramers of TTR. Acta Cryst. D57, 957-967. [Abstract] ; PDB:[1ICT]