Sensory Research in Göttingen
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Löwel, Siegrid, Prof. Dr.


Professor for Systems Neuroscience and Neurostimulation, BFNT and School of Biology, Universität Göttingen

- Studies of Biology, Julius-Maximilians-Universität, Würzburg and Johann-Wolfgang-Goethe-Universität, Frankfurt am Main, 1978-1985

- Diploma Thesis, Universität Frankfurt am Main, 1985

- PhD-thesis, Universität Frankfurt am Main, 1988

- Research Assistant, Dept. Neurophysiology (Head: Prof. Dr. Wolf Singer),
Max-Planck-Institut für Hirnforschung, Frankfurt am Main, 1990-1997

- Head of the Research Group "Visual Development and Plasticity", Leibniz-Institut für Neurobiologie, Magdeburg, 1997-2002 & 2004-2005

- Associate Research Physiologist/Research Associate Professor, School of Medicine, Department of Physiology, University of California in San Francisco (UCSF), U.S.A., 2002-2003

- Dorothea-Erxleben-Guest Professorship, Otto-von-Guericke-Universität Magdeburg (http://www.unimagdeburg.de/gleichstellungsbuero/gleich/erxleb.htm), 2003-2004

- Scholarship in the Hertie-Excellency Program "Neurosciences"(www.ghst.de), 2004-2005

- Professor of Neurobiology, Friedrich-Schiller-Universität Jena, 2005-2010

- Professor of Systems Neuroscience, School of Biology, University of
Göttingen since 2010


Major Research Interests

The Löwel lab is focussed on understanding the development and plasticity of neuronal circuits in the mammalian cortex. We use a combination of techniques, including optical imaging, physiology, neuroanatomy and modelling to explore how experience and learning influence the structure and function of nerve cell networks and how activity patterns and genetic factors influence these processes. We hope that answering these key questions not only helps to understand the rules underlying brain development, functioning and learning but additionally will open up new avenues to develop clinically relevant concepts to promote regeneration and rehabilitation for diseased and injured brains.


Homepage Department/Research Group:

http://www.uni-goettingen.de/en/190976.html
http://systemsneuroscience.uni-goettingen.de/index.html


Selected Recent Publications:

- Krempler K, Schmeer C, Tausch S, Isenmann S, Witte OW, Löwel S (2010) Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice. Invest Ophthalmol Vis Sci, in press.

- Kaschube M, Schnabel M, Löwel S, Coppola DM, White LE, Wolf F (2010) Universality in the evolution of orientation columns in the visual cortex. Science 330:1113-1116 (published online Nov. 4, 2010, DOI: 10.1126/science.1194869).

- Keary N, Voß J, Lehmann K, Bischof H-J, Löwel S (2010) Optical imaging of retinotopic maps in a small songbird, the zebra finch. PLoS ONE 5: e11912. doi:10.1371/journal.pone.0011912.

- Thygarajan S, van Wyk M, Lehmann K, Löwel S, Feng G, Wässle H (2010) Visual function in retinal degeneration mice and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 30: 8745-8758.

- Keil W, Schmidt K-F, Löwel S, Kaschube M (2010) Reorganization of columnar architecture in the growing visual cortex. Proc Natl Acad Sci U S A 107: 12293-12298.

- Goetze B, Schmidt K-F, Lehmann K, Altrock WD, Gundelfinger ED, Löwel S (2010) Vision and visual cortical maps in mice with a photoreceptor synaptopathy: reduced but robust visual capabilities in the absence of synaptic ribbons. Neuroimage 49:1622-1631.

- Kaschube M et al. (2009) Interareal coordination of columnar architectures during visual cortical development. Proc Natl Acad Sci U S A 106: 17205-17210.

- Reichl L, Löwel S, Wolf F (2009) Pinwheel stabilization by ocular dominance segregation. Phys Rev Lett 102: 208101.

- Lehmann K, Löwel S (2008) Age-dependent ocular dominance plasticity in adult mice. PLoS ONE 3:e3120.

- Schmidt K-F, Löwel S (2006) Optical imaging in cat area 18: Strabismus does not enhance the segregation of ocular dominance domains. Neuroimage 29:439-445.

- Cang J, Kalatsky V, Löwel S, Stryker MP (2005) Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse. Visual Neurosci 22:685-691.








Siegrid Löwel

Address
Prof. Dr. Siegrid Löwel
Systems Neuroscience Group
Johann-Friedrich-Blumenbach-Institute of Zoology and Anthropology
Bernstein Focus for Neurotechnology
University of Göttingen
Von-Siebold-Str. 4
37075 Göttingen
Tel.: +49-(0)551-39 20161/60
Fax: +49-(0)551-39 20162
siegrid.loewel@biologie.uni-goetting
en.de