From single cells to filaments (yeast vs. pseudohyphae)
S. cerevisiae is an example of a dimorphic fungus which can switch between a non-adherent single cell (yeast) and an adherent filamentous (pseudohyphae) form. Adhesion can be an initial step in infection or biofilm formation. The dimorphic switch requires cAMP/PKA and MAPK signalling pathways. The highly conserved Asc1p/RACK1 presumably forms a ribosomal hub for signaling pathways transferring information to the mRNA-translation machinery. We analyse the Asc1p/RACK1 control of translation of pathway-specific transcription factors using a proteomic approach.
Dr. Oliver Valerius
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