Wirths, Oliver, Prof. Dr.*



  • 1994 - 1999 Diploma in Biology, University of Bonn, Bonn, Germany
  • 1999 - 2003 Ph.D. at University of Bonn and Catholic University Leuven
  • 2003 - 2004 Post-Doctoral fellow at Saarland University, Homburg
  • 2004 - 2006 Research Assistant at Saarland University, Homburg
  • Since 2006 Laboratory head and project leader at the Molecular Psychiatry lab, University Medical Center Göttingen
  • 2012 Habilitation (Venia legendi) in Molecular Neurosciences, University Medical Center Göttingen
  • Since 2017 Apl. Professorship, University Medical Center Göttingen



Major Research Interests

Neurobiology and biochemistry of Alzheimer’s Disease (AD), transgenic mouse models of neurodegenerative diseases (neuropathology, biochemistry, expression profiling and behavioral analysis), exercise and neurodegeneration, truncated Aβ variants in AD



Homepage Department/Research Group

https://www.researchgate.net/profile/Oliver_Wirths
http://loop.frontiersin.org/people/10202/overview


Selected Recent Publications


  • Walter S., Jumpertz T., Hüttenrauch M., Ogorek I., Gerber H., Storck S.E., Zampar S., Dimitrov M., Lehmann S., Lepka C., Berndt C., Wiltfang J., Becker-Pauly C., Beher D., Pietrzik C.U., Fraering P., Wirths O*. and Weggen S*. (2019) The metalloprotease ADAMTS4 generates N-truncated Aβ4-x peptides and marks oligodendrocytes as a pro-amyloidogenic cell lineage in Alzheimer’s disease. Acta Neuropathologica, 137(2): 239-257 (*corresponding authors)

  • Hüttenrauch M., Ogorek I., Klafki H.W., Otto M., Stadelmann-Nessler C., Weggen S., Wiltfang J. Wirths O. (2018) Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia. Acta Neuropathologica Communications, 6(1):108

  • Wirths O., Walter S., Kraus I., Klafki H.W., Oberstein T., Ghiso J., Wiltfang J., Bayer T.A., Weggen S. (2017) N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models. Alzheimer’s Research & Therapy, 9: 80

  • Saul A., Wirths O. (2017) Endogenous Apolipoprotein E (ApoE) fragmentation in transgenic mouse models of Alzheimer’s disease. Molecular Neurobiology, 54: 319-327

  • Hüttenrauch M., Brauß A., Kurdakova A., Borgers H., Klinker F., Liebetanz D., Salinas-Riester G., Wiltfang J., Klafki H.W., Wirths, O. (2016) Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model. Translational Psychiatry, 6:e800