Ebert, Antje, Dr.
Research group leader at the Department of Cardiology and Pneumology
- 2010 PhD at Heidelberg University, Biochemistry Center (Graduate Research College 1188)
- 2010 - 2015 Postdoctoral fellow at Stanford University School of Medicine, Cardiovascular Institute (DFG fellowship); Department of Chemical and Systems Biology (Associated member)
- 2015 - 2016 Instructor at Stanford University School of Medicine, Cardiovascular Institute; Department of Chemical and Systems Biology (Associated member)
- since 2016 Research group leader at the University Medical Center Göttingen, Department of Cardiology and Pneumology
Major Research Interests
Molecular interactions and signaling in cardiomyopathy
Key functions in cellular metabolism and homeostasis are maintained by mitochondria. Dysfunctions in metabolic turnover and mitochondrial function contribute to many pathogenic disorders. Our group studies the interdependencies between mitochondrial function, metabolism and cellular homeostasis in cardiomyocytes and the cardiac vasculature. Particularly, we are interested in regulation of redox stress-mediated mechanisms by metabolic function and mitochondrial dynamics. We utilize a human model system of patient-specific, induced pluripotent stem cells (iPSCs), in combination with site-specific genome editing, as well as biochemical and systems biology methods. With these tools we investigate the consequences of genetic variants which cause cardiomyopathies, such as dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).
Our goals are to understand molecular signaling functions in cardiac health and disease, integrating systems medicine approaches. With our research, we aim to contribute to possible future therapeutic directions in cardiovascular disease.
Homepage Department/Research Group
Selected Recent Publications
- Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC (2016) iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nat Cell Biol. 2016 Oct;18(10):1031-42
- Riegler J, Tiburcy M, Ebert AD, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC (2015) Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res. 2015 Aug 19
- Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC (2014) Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system. Sci Transl Med. 2014 Sep 24;6(255):255ra130
- Sanchez-Freire V, Ebert AD, Kalisky T, Quake SR, Wu JC (2012) Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Nature Protocols 2012 Apr 5;7(5):829-38
- Ebert AD, Laussmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W (2010) Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic. 2010 Jun;11(6):813-26