Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences

Müller, Michael, Prof. Dr.


  • 1996 Dr. rer. nat. (Biology) University of Düsseldorf
  • 1996-1997 Postdoc (Laboratory of W. R. Schlue, Düsseldorf)
  • 1997-1999 Postdoc (Laboratory of G.G. Somjen, Duke University, Durham, USA)
  • 2000-2001 Postdoc (Laboratory of K. Ballanyi, Göttingen)
  • 2001-2003 Postdoc (Laboratory of D.W. Richter/ S.L. Mironov, Göttingen)
  • 2004-2010 Junior Professor of Molecular Neurophysiology and Group Leader
  • since 2010 apl. Professor and tenured position




Major Research Interests

Two-photon microscopy and high resolution imaging, subcellular imaging of redox dynamics, neuronal network dysfunction in Rett syndrome, mitochondrial dysfunction and organelle crosstalk, mechanisms of cerebral ischemia and spreading depression, (sub)cellular generation and signaling function of reactive oxygen species, responses of central neurons and glial cells to metabolic disturbances, modulation of neuronal networks by redox changes.


Homepage Department/Research Group

https://www.neuro-physiol.med.uni-goettingen.de/wordpress/prof-dr-michael-mueller/


Selected Recent Publications


  • Ackermann, M.A., Buchholz, S.M., Dietrich, K., Müller M. (2024). Quantitative, real-time imaging of spreading depolarization-associated ROS production. Front. Cell. Neurosci. 18: 1465531.
  • Golubiani G., Lagani V., Solomonia R., Müller M. (2021). Metabolomic fingerprint of MeCP2-deficient mouse cortex: evidence for a pronounced multi-facetted metabolic component in Rett syndrome. Cells 10: 2494.
  • Müller M. (2019). Disturbed redox homeostasis and oxidative stress: Potential players in the developmental regression in Rett syndrome. Neurosci. Biobehav. Rev. 98: 154-163.
  • Wagener K.C., Kolbrink B., Dietrich K., Kizina K.M., Terwitte L.S., Kempkes B., Bao G., Müller M. (2016). Redox-indicator mice stably expressing genetically-encoded neuronal roGFP: Versatile tools
    to decipher subcellular redox dynamics in neuropathophysiology. Antioxid. Redox Signal. 25: 41-58.
  • Weller J., Kizina K.M., Can K., Bao G., Müller M. (2014). Response properties of the genetically-encoded optical H2O2 sensor HyPer. Free Rad. Biol. Med. 76: 227-241.