Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences

Steinem, Claudia, Prof. Dr.


  • 1987 – 1994 Studies in Biology and Chemistry and Diploma in Chemistry, University of Münster, Prof. Dr. H.-J. Galla
  • 1994 – 1997 Doctior in Chemistry, University of Münster, Prof. Dr. H.-J. Galla
  • 1997 Postdoctoral Researcher, Institute of Biochemistry, University of Münster
  • 1997 – 1998 Postdoctoral Fellow, Scripps Research Institute, La Jolla, California, USA
  • 1999 – 2001 Habilitation in Biochemistry, Institute of Biochemistry, University of Münster, Prof. Dr. H.-J. Galla
  • 2001 – 2006 Associate professor for Bioanalytics and Biosensors, University of Regensburg
  • 2006 Full professor for Biomolecular Chemistry, University of Göttingen
  • since 2017 MPG fellow of the Max-Planck Institute for Dynamics and Self-Organization, Göttingen



Major Research Interests


New artificial membrane systems based on highly ordered porous substrates; Functional insertion of ion channels and protein pumps; Development and application of fusion assays; Quantification and visualization of protein-membrane and protein-cytoskeleton interactions; Hierarchical silica formation in vitro


Homepage Department/Research Group

http://www.uni-goettingen.de/de/213067.html



Selected Recent Publications



  • Gerdes B, Rixen RM, Kramer K, Forbrig E, Hildebrandt P, Steinem C (2018) Quantification of Hv1-induced proton translocation by a lipid-coupled Oregon Green 488-based assay. Anal. Bioanal. Chem. 410, 6497–6505. DOI:10.1007/s00216-018-1248-7
  • Nöding H, Schön M, Reinermann C, Dörrer N, Kürschner A, Geil B, Mey I, Heussinger C, Janshoff A, Steinem C (2018) Rheology of membrane-attached minimal actin cortices. J. Phys. Chem. B. 122, 4537-4545. DOI: 10.1021/acs.jpcb.7b11491
  • Schütte OM, Mey I, Enderlein J, Savic F, Geil B, Janshoff A, Steinem C (2017) Size and mobility of lipid domains tuned by geometrical constraints. Proc. Natl. Acad. Sci. U. S. A. 114, E6064-E6071. DOI: 10.1073/pnas.1704199114
  • Schwamborn M, Schumacher J, Sibold J, Teiwes NK, Steinem C (2017) Monitoring ATPase induced pH changes in single proteoliposomes with the lipid-coupled fluorophore Oregon Green 488. Analyst 14, 2670-2677. DOI: 10.1039/C7AN00215G
  • Kuhlmann JW, Junius M, Diederichsen U, Steinem C (2017) SNARE-mediated single-vesicle fusion events with supported and freestanding lipid membranes. Biophys. J. 112, 2348-2356. DOI: 10.1016/j.bpj.2017.04.032
  • Gleisner M, Kroppen B, Fricke C, Teske N, Kliesch TT, Janshoff A, Meinecke M, Steinem C (2016) Epsin N-terminal homology domain (ENTH) activity as a function of membrane tension. J. Biol. Chem. 291, 19953-19961. DOI: 10.1074/jbc.M116.731612
  • Rost U, Steinem C, Diederichsen U (2016) Beta-Glutamine-mediated self-association of transmembrane beta-peptides within lipid bilayers. Chem. Sci. 7, 5900-5907. DOI: 10.1039/C6SC01147K
  • Schütte OM, Mey I, Enderlein J, Savic F, Geil B, Janshoff A, Steinem C (2017) Size and mobility of lipid domains tuned by geometrical constraints. Proceedings of the National Academy of Sciences 114(30) DOI:10.1073/pnas.1704199114.
  • Gleisner M, Kroppen B, Fricke C, Teske N, Kliesch TT, Janshoff A, Meinecke M, Steinem C (2016) Epsin N-terminal Homology Domain (ENTH) Activity as a Function of Membrane Tension. Journal of Biological Chemistry 291(38) DOI:10.1074/jbc.m116.731612.
  • Ludolphs M, Schneeberger D, Soykan T, Schäfer J, Papadopoulos T, Brose N, Schindelin H, Steinem C (2015) Specificity of Collybistin-Phosphoinositide Interactions. Journal of Biological Chemistry 291(1) DOI:10.1074/jbc.m115.673400.
  • Rost U, Steinem* C, Diederichsen* U (2016) β-Glutamine-mediated self-association of transmembrane β-peptides within lipid bilayers. Chemical Science 7(9) DOI:10.1039/c6sc01147k.
  • Schütte OM, Ries A, Orth A, Patalag LJ, Römer W, Steinem* C, Werz* DB (2014) Influence of Gb3 glycosphingolipids differing in their fatty acid chain on the phase behaviour of solid supported membranes: chemical syntheses and impact of Shiga toxin binding. Chemical Science 5(8) DOI:10.1039/c4sc01290a.
  • Braunger JA, Brückner BR, Nehls S, Pietuch A, Gerke V, Mey I, Janshoff A, Steinem C (2014) Phosphatidylinositol 4, 5-Bisphosphate Alters the Number of Attachment Sites between Ezrin and Actin Filaments. Journal of Biological Chemistry 289(14) DOI:10.1074/jbc.m113.530659.
  • Song C, Weichbrodt C, Salnikov ES, Dynowski M, Forsberg BO, Bechinger B, Steinem C, de Groot BL, Zachariae U, Zeth K (2013) Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proceedings of the National Academy of Sciences 110(12) DOI:10.1073/pnas.1214739110.
  • Lazzara TD, Carnarius C, Kocun M, Janshoff A, Steinem C (2011) Separating Attoliter-Sized Compartments Using Fluid Pore-Spanning Lipid Bilayers. ACS Nano 5(9) DOI:10.1021/nn201266e.
  • Bernecker A, Wieneke R, Riedel R, Seibt M, Geyer A, Steinem C (2010) Tailored Synthetic Polyamines for Controlled Biomimetic Silica Formation. Journal of the American Chemical Society 132(3) DOI:10.1021/ja9061163.
  • RömerW, Berland L, Chambon V, Gaus K, Windschiegl B, Tenza D, Aly MRE, Fraisier V, Florent JC, Perrais D, Lamaze C, Raposo G, Steinem C, Sens P, Bassereau P, Johannes L (2007) Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature 450(7170) DOI:10.1038/nature05996.