Prof. Dr. Argyris Papantonis
- 2002–2008 Ph.D., National & Kapodistrian University of Athens, Greece
- 2008–2013 Postdoctoral fellow, Oxford University, United Kingdom
- 2012–2013 Lecturer for Biochemistry, University College Oxford, United Kingdom
- 2009 Grad Junior Group Leader for Systems Biology, University of Cologne, Germany
- since 2018 Professor of Translational Epigenetics, University Medical Center Göttingen, Germany
Major Research Interests
We wish to uncover the rules governing gene expression in response to developmental and extra-cellular cues. Genome architecture is thought to be a major determinant in this. What we strive to understand is how chromatin (re)folds to accommodate responses to such cues in 3D nuclear space and dynamically over time. In the end, we anticipate these rules to be general ones, which once deciphered will allow us to predict how a cell might respond upon signalling, in the context of disease, or during cellular ageing.
Homepage Department/Research Group
Selected Recent Publications
- Mizi A, Zhang S, Papantonis A* (2020) Genome folding and refolding in differentiation and cellular senescence. Curr Opin Cell Biol 67: 56-63
- Casa V, Moronta Gines M, Gade Gusmao E, Slotman JA, Zirkel A, Josipovic N, Oole E, van IJcken WFJ, Houtsmuller AB, Papantonis A*, Wendt KS* (2020) Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcriptional control. Genome Res 30: 515-527
- Weiterer SS, Meier-Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, Brant L, Mayr-Buro C, Jurida L, Beuerlein K, Müller H, Weber A, Tenekeci U, Dittrich-Breiholz O, Bartkuhn M, Nist A, Stiewe T, van IJcken WF, Riedlinger T, Schmitz ML, Papantonis A*, Kracht M* (2020) Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39:e101533
- Rada-Iglesias A, Grosveld FG, Papantonis A (2018) Forces driving the three-dimensional folding of eukaryotic genomes. Mol Syst Biol. 14:e8214.
- Zirkel A, Nikolic M, Sofiadis K, Mallm JP, Brackley CA, Gothe H, Drechsel O, Becker C, Altmüller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, Koker M, Gusmao EG, Costa IG, Ullrich RT, Wagner W, Roukos V, Nürnberg P, Marenduzzo D, Rippe K, Papantonis A (2018) HMGB2 loss upon senescence entry disrupts genomic organization and induces CTCF clustering across cell types. Mol Cell 70:730-744.
- Brant L, Georgomanolis T, Nikolic M, Brackley CA, Kolovos P, van Ijcken W, Grosveld FG, Marenduzzo D, Papantonis A (2016) Exploiting native forces to capture chromosome conformation in mammalian cell nuclei. Mol Syst Biol. 12:891.
- Kolovos P, Georgomanolis T, Koeferle A, Larkin JD, Brant L, Nikolicć M, Gusmao EG, Zirkel A, Knoch TA, van Ijcken WF, Cook PR, Costa IG, Grosveld FG, Papantonis A (2016) Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response. Genome Res. 26:1478-1489.
- Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response. Genome Res. 26:1478-1489., Papantonis A (2016) Isolation of the protein and RNA content of active sites of transcription from mammalian cells. Nat Protoc. 11:553-565.
- Kelly S, Georgomanolis T, Zirkel A, Diermeier S, O'Reilly D, Murphy S, Längst G, Cook PR, Papantonis A (2015) Splicing of many human genes involves sites embedded within introns. Nucleic Acids Res. 43:4721-4732.