Oudelaar, A. Marieke, Dr.

Lise Meitner Group Leader at the Max Planck Institute for Multidisciplinary Sciences

• Since 2020: Lise Meitner Group Leader, Genome Organization and Regulation, Max Planck Institute for Multidisciplinary Sciences, Göttingen
• 2018-2020: Junior Research Fellow, University of Oxford, United Kingdom
• 2014-2018: Predoctoral fellow, University of Oxford, United Kingdom

Major Research Interests
Precise patterns of gene expression in metazoans are controlled by the cis-regulatory elements of the genome, which include enhancers and promoters. The spatial organization of the genome in the nucleus is important for accurate communication between these elements. Enhancers and promoters interact in 3D chromatin structures, which allow for specific communication between elements that are separated by large genomic distances. These enhancer-promoter interactions are important to establish accurate gene expression patterns during differentiation and development.
The aim of our research is to understand how 3D chromatin structures are formed and how the cis-regulatory elements function within this context to control gene expression. To this end, we develop high-resolution Chromosome Conformation Capture (3C) techniques, which we use in combination with other genomic techniques, genetic perturbations, and computational approaches. We focus on the interplay between genome organization and regulation during mammalian differentiation, and how perturbations in these processes contribute to human disease, including cancer.

Homepage Department / Research Group
https://www.mpinat.mpg.de/oudelaar

ORCID: 0000-0002-4016-6158