Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences

Krisko, Anita, Dr.*


  • 2019 – present, Heisenberg position, Department of Experimental Neurodegeneration, University Medical Center, Göttingen, Germany
  • 2012 – 2019, group leader, Mediterranean Institute for Life Sciences, Split, Croatia
  • 2007 – 2012, senior postdoctoral fellow, INSERM U1001, Faculté de Medecine Paris 5, Paris, France
  • 2006 – 2007, postdoctoral fellow, Equipe de Bioinformatique Genomique et Moleculaire, Université Denis Diderot – Paris 7, Paris, France
  • 2002 – 2005, PhD student, Molecular biophysics, Rudjer Boskovic Institute, Zagreb, Croatia
  • 2001: BSc, Molecular biology, University of Zagreb, Croatia



Major Research Interests

Our group seeks to understand the interplay between RNA and protein homeostasis and the cellular metabolic activity, as well as the role it has in cellular quality control. We focus on elucidation of cellular and molecular mechanisms underlying the ribostasis-proteostasis-metabolism crosstalk within and across cellular compartments. We aim to obtain an integrated picture of the effects that the quality of macromolecular folding environment is able to yield on cellular metabolism, thus contributing to understanding of the implications of this multifaceted network in aging and disease. Understanding this crosstalk may reveal novel insights into basic cellular functioning, and shed new light on the process of aging, and neurodegenerative diseases.


Homepage Department/Research Group
https://www.neurodegeneration.uni-goettingen.de/dr-anita-krisko/


Selected Recent Publications


  • Sathyanarayanan U, Musa M, Bou Dib P, Raimundo N, Milosevic I, Krisko A. ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo. 2020, Nat Commun. 11: 5226.

  • Peric M, Musa M, Bou Dib P, Sobocanec S, Saric A, Lovric A, Rudan M, Nikolic A, Milosevic I, Vlahovicek K, Raimundo N, Kriško A. Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling. 2019, Aging, 10: 2407-2427.

  • Rudan M, Bou Dib P, Musa M, Kanunnikau M, Sobocanec S, Rueda D, Warnecke T*, Kriško A*. Normal mitochondrial function in Saccharomyces cerevisiae requires inefficient splicing. eLife 2018; 7:e35330. *equal contribution

  • Perić M, Lovrić A, Šarić A, Musa M, Bou Dib P, Rudan M, Nikolic A, Sobocanec S, Mikecin AM, Dennerlein S, Milosevic I, Vlahovicek K, Raimundo N, Kriško A. TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan. Aging Cell 2017; 16: 994-1005.

  • Rudan M, Schneider D, Warnecke T*, Kriško A*. RNA chaperones buffer deleterious mutations in E. coli. eLife 2015; 4:e04745. *equal contribution

  • Vidovic A, Supek F, Nikolic A, Kriško A. Signatures of conformational stability and oxidation resistance in proteomes of pathogenic bacteria. Cell Reports 2014; 7: 1393-1400.