Neurosciences (MSc/PhD/MD-PhD)

Florian Kremser

EDUCATION

College / University

Georg-August-Universität Göttingen

Highest Degree

Bachelor of Science

Major Subjects

Molecular Medicine
Kremser

Germany

Lab Experience

iPSC culture, organoids, assembloids, functional assays, optogenetics, immunohistochemistry, confocal microscopy (Spinning disc), mice dissection, organotypic slice cultures (cerebellum), biocytin filling of neurons, genotyping, qPCR, SDS-PAGE, microinjection, live cell imaging, bacterial cell culture, heterologous protein expression, Sanger sequencing

Projects / Research

  • May - Sept 2025 – Bachelor´s thesis “Investigating Purkinje cell developmental abnormalities in mouse models of spinocerebellar ataxia” Nuffield Department of Clinical Neurosciences, University of Oxford with Prof. Dr. Esther Becker
  • Aug - Nov 2024 - ”Generation of innervated engineered skeletal muscle Assembloids- a model to study the neuromuscular junction and related disease” Department of Pharmacology and Toxicology, University Medical Centre Göttingen (UMG) with Dr. Arne Hofemeier, Dr. Maria Patapia Zafeiriou and Prof. Dr. Wolfram H. Zimmermann
  • Feb – Apr 2024 - ”Elucidating differences in amyloid pathology between two mouse models of Alzheimer’s disease” Molecular degeneration group, Department of molecular Psychiatry, UMG with Prof. Dr. Oliver Wirths
  • Apr 2024 – May 2025 - Student research assistant- Cytoskeletal dynamics in oocytes Dr. Peter Lenart, Max-Planck Institute for Multidisciplinary Sciences

Scholarships / Awards

2025 – 2026: Stipend by the International Max Planck Research School

SCIENTIFIC INTERESTS AND GOALS

My passion lies in understanding the fundamental principles that govern neuronal development and how their disruption can lead to disease. In this regard, I am particularly interested in the potential of organoid and assembloid technologies to model these processes in vitro. By harnessing the tissues' self-organising properties, I hope to develop more sophisticated model systems capable of probing cellular and molecular mechanisms that lead to diseases that are targetable by molecular interventions. I believe that fundamental research on the model systems we use can significantly enhance their effectiveness in studying clinically relevant diseases. One of my major interests is applying these models to better understand neuromuscular diseases that impair motor function, such as amyotrophic lateral sclerosis, myasthenia gravis and Duchenne muscular dystrophy. Additionally, I am also eager to learn about more complex neural circuits, such as the ones responsible for driving learning and cognition.