Manas Kulkarni

EDUCATION

College / University

Vellore Institute of Technology (VIT)

Highest Degree

Bachelor of Technology

Major Subjects

Biotechnology

Country

India

Lab Experience

Fluorescence Microscopy, Confocal microscopy, Fluorescence spectroscopy, Flow Cytometry, LASX Leica microscopy software, Immunocytochemistry & Cell Staining, Antibody-based Receptor Internalization Assays, Cell Culture, SDS-PAGE, PCR, Cell Viability Assays, Thin-layer Chromatography, Protein Purification, Protein Quantification, FiJi Image Analysis, Colocalization Analysis, Graphpad Prism, OriginPro 8.5

Projects / Research

  • 2026: "Deciphering the Mechanism of Altered Trafficking of a G Protein-Coupled Receptor in a Cellular Model of Smith-Lemli-Opitz Syndrome (SLOS)", Chattopadhyay Lab, Council of Scientific and Industrial Research (CSIR), Centre for Cellular and Molecular Biology (CCMB), Hyderabad
  • 2025: "Synthetic Production of Ambrein in Escherichia coli", International Genetically Engineered Machine (iGEM), VIT Vellore
  • 2025: "Antibacterial and Anti-biofilm Activity of a D-Limonene/ZnO Nanoemulsion against Pseudomonas aeruginosa", Gothandam Lab, VIT Vellore

Scholarships / Awards

SCIENTIFIC INTERESTS AND GOALS

My scientific interests lie in understanding how neurons communicate at the molecular level and how disruptions in these processes contribute to neurological disease. I am fascinated by the mechanisms underlying synaptic signalling, including how receptors and other cellular components are regulated, trafficked, and organised within neurons to ensure precise communication between cells. I am interested in understanding how such alterations can disrupt neural communication and ultimately affect neuronal function. My previous research experience has strengthened my interest in the relationship between cellular homeostasis and neuronal signalling. In particular, my work investigating altered membrane composition and neuronal receptor trafficking in a cellular model of SLOS introduced me to the intricate relationship between membrane biology, receptor dynamics, and cellular function. This experience motivated me to explore more deeply how molecular alterations can influence neuronal communication. Going forward, I am excited to investigate the molecular mechanisms contributing to disrupted neural communication, with particular interest in neurodevelopmental disorders and neurodegenerative diseases. I am also drawn to the interdisciplinary nature of neuroscience and the opportunity to integrate principles from physics, chemistry and mathematics to understand complex biological processes. I believe that approaching biological questions from multiple perspectives can provide a more comprehensive understanding of the mechanisms underlying neuronal function and dysfunction.