Großhans, Jörg, Prof. Dr.

Professor of Developmental Biochemistry

  • 1993 Diplom Biochemistry, Tübingen
  • 1993-1996 Doctoral research with C Nüsslein-Volhard, Max-Planck-Institut für Entwicklungsbiologie, Tübingen
  • 1997-2001 Post-doc with E Wieschaus, Princeton (USA)
  • 2002-2008 ZMBH and Emmy-Noether research group, Heidelberg
  • since 2009 Professor, Universitätsmedizin Göttingen

Major Research Interests

Biological structure formation/morphogenesis and ageing.
Our group is interested in the molecular and cell-biological mechanisms how biological structures are formed. Specifically we investigate epithelial morphogenesis (epithelial compartment formation, role of actin dynamics and Rho signalling), how cell cycle modes switch and how the slam RNA-protein complex controls membrane invagination. Recently we started to apply quantitative and biophysical approaches. We also study control of nuclear size and shape and its link to ageing.

Homepage Department/Research Group

Selected Recent Publications

  • Winkler F, Kriebel M, Clever M, Gröning S, Großhans J (2017) Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles in Drosophila. G3 7 2305–2314.
  • Liu B, Großhans J (2017) Link of zygotic genome activation and cell cycle control. Meth Mol Biol 1605 11-30.
  • Kong D, Wolf F, Großhans J (2017) Forces directing germ-band extension in Drosophila embryos. Mech Dev 144 11-22.
  • Lv Z, Großhans J (2016) A radial actin network in apical constriction. Dev Cell 39 280-282.
  • Koke C, Kanesaki T, Großhans J, Schwarz US, Dunlop CM (2014) A computational model of nuclear self-organisation in syncytial embryos. J Theor Biol 359 92-100.
  • Zhang Y, Kong D, Reichl L, Vogt N, Wolf F, Großhans J (2014) The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Dev Biol, 390 208-220.
  • Bogdan S, Schulz J, Großhans J (2013) Formin' cellular structures - physiological roles of Diaphanous (Dia) in actin dynamics. (review). Comm Integ Biol 6 e27634.
  • Yan S, Lv Z, Winterhoff M, Wenzl C, Zobel T, Faix J, Bogdan S, Großhans J (2013) The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. J Cell Sci 126 1796-1805.
  • Sung H-W, Spangenberg S, Vogt N, Großhans J (2013) Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription. Curr Biol 23 133-138.
  • Albrecht SC, Barata A, Großhans J, Teleman AA, Dick TP (2011) In vivo mapping of hydrogen peroxide and oxidaized glutathione reveals chemical and regional specificity of redox homeostasis. Cell metabolism 14 819-829
  • KanesakiT, EdwardsC, Schwarz U, Großhans J (2011) Dynamic ordering of nuclei in syncytial embryos: a quantitative analysis of the role of cytoskeletal networks. Integ Biol 3 1112-1119.