Outeiro, Tiago Fleming, Prof. Dr.
Director of the Department of Experimental Neurodegeneration
- 11/2010 –present: Full Professor of Aggregopathies, Director of the Department of Neurodegeneration and Restaurative Research, University Medizin Gottingen, Gottingen, Germany
- 12/07 – present Auxiliar Professor, Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Portugal
- 5/07 – 7/08 Visiting Scientist, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
- 5/07 – 1/11 Principal Investigator and Group Leader at Instituto de Medicina Molecular, Lisbon, Portugal
- 6/04-5/07 Postdoctoral Research Fellow; advisor Dr. Brad Hyman, MGH – Harvard University, USA
- 6/04-9/04 Consultant and Research Scientist, FoldRx Pharmaceuticals, Inc, Cambridge, USA: Ph.D. work was transferred to the start up company FoldRx Pharmaceuticals, Inc.
- 4/99 – 7/04 Ph.D. in Molecular and Cell Biology Whitehead Institute for Biomedical Research, MIT, Cambridge, USA University of Chicago (UC), Chicago, USA
- 9/94-9/98 B.S. in Biochemistry Faculty of Sciences – University of Porto, Porto, Portugal
Major Research Interests
Our research interests are focused on the understanding of the molecular mechanisms which lead to neurodegeneration in diseases such as Parkinson's, Huntington's, or Alzheimer's disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain.
Because the molecular pathways involved in protein homeostasis are highly conserved, we employ a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.
We are also developing novel in vivo imaging approaches based on multi-photon microscopy to observe protein misfolding and aggregation in the living brain.
Our ultimate goals are to develop novel therapeutic approaches for these and other related disorders. We are working closely together with clinicians in order to accelerate drug discovery efforts, translating basic research into clinical applications that will improve the lives of patients.
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Selected Recent Publications