Dobbelstein, Matthias, Prof. Dr.

Professor of Molecular Oncology

• 1993 Dr. med., University of Munich, Germany
• 1993 – 1996 Postdoctoral fellow, Princeton University, USA
• 1997 – 2004 Group leader, University of Marburg, Germany
• 2004 – 2005 Professor of Molecular Oncology, University of Southern Denmark, Odense
• since 2005 Head of the Department of Molecular Oncology, Georg-August-Universität Göttingen, Germany
• since 2022 Fellow, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany

Major Research Interests
Our group is studying the tumor suppressor p53 and its antagonist MDM2. The MDM2 oncoprotein affects cancer cell growth in multiple ways, and we strive to understand how this works. This includes the impact of MDM2 on chromatin, DNA replication and intracellular signaling pathways.
Exploring the mechanisms of cancer chemotherapy, we began to analyze how chemotherapeutics affect virus replication. This led us to a new area of our research, the pharmacotherapy of virus infections. In particular, we are asking how nucleoside analogues interfere with the replication of infectious organisms, including SARS-CoV-2, influenza viruses, and parasites.

Homepage Department/Research Group
https://molonc.umg.eu/research/dobbelstein-lab/
https://www.mpinat.mpg.de/dobbelstein

ORCID: 0000-0001-5052-3967