Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

PD Dr. rer. nat Sven Thoms


  • 1998–2002 Ph.D., Friedrich-Miescher-Laboratory of Max-Planck-Gesellschaft in Tübingen, Germany
  • 2002–2006 Postdoctoral fellow, Ruhr-University of Bochum, Germany
  • 2007–2013 Postdoctoral fellow, Institute of Child and Adolescent Health, University Medical Center, Göttingen, Germany
  • since 2013 Group leader Institute of Child and Adolescent Health, University Medical Center, University Medical Center Göttingen, Germany



Major Research Interests


    Cell organelles: (Peroxisomes and T-tubule system): Biochemistry, Molecular Cell Biology, Biogenesis, Diseases
    Translational Readthrough: Molecular Biology of endogenous functional readthrough, Cellular function, Mechanism, Readthrough therapy of diseases caused by premature stop codon mutations (rare diseases, cancers, neurological disorders)




Selected Recent Publications


  • Yofe I, Soliman K, Chuartzman SG, Morgan B, Dick TP, Cooper SJ, Ejsing CS, Schuldiner M*, Zalck¬var E*, Thoms, S. (2017) Pex35 is a new regulator of peroxisome abundance. Journal of Cell Science, 130: 791-804 (*corresponding author)

  • Hofhuis J, Bersch K, Büssenschütt R, Drzymalski M, Cierny I, Liebetanz D, Nikolaev VO, Wagner S, Maier LS, Gärtner J, Klinge L*, Thoms S* (2017). Dysferlin links T-tubule biogenesis to skeletal muscle disease through membrane tubulation. Journal of Cell Science 130: 841-852. (*corresponding author)

  • Schueren F, Thoms S* (2016) Functional translational readthrough – a systems biology perspective.PLOS Genetics 12:e1006196. (*corresponding author)

  • Nötzel C, Lingner T, Klingenberg H, Thoms S* (2016) Identification of new fungal peroxisomal matrix proteins and revision of the PTS1 consensus. Traffic 17, 1110-1124.(*corresponding author)

  • Hofhuis J, Schueren F, Lingner T, Gärtner J, Jahn O, Thoms S* (2016). The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code. Open Biology 6:160246.(*corresponding author)

  • Buentzel J, Vilardi F, Lotz-Havla A, Gärtner J, Thoms S* (2015). Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins. Sci Rep5:17420.(*corresponding author)

  • Schueren F, Lingner T, George R, Hofhuis J, Dickel C, Gärtner J*, Thoms S* (2014) Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals. Elife 3, e03640. (*corresponding author)