Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Fornasiero, Eugenio, PhD

Group Leader in the Department of Neuro-sensory Physiology


  • Bachelor and Master in Medical Biotechnology; University of Modena, Italy, 2000 – 2005
  • Ph.D. in Cell and Molecular Biology; San Raffaele, Milan, Italy and VIB, Leuven, Belgium, 2010
  • Postdoctoral fellow at San Raffaele Institute, Milan, Italy with Prof. Flavia Valtorta, 2010 – 2012
  • Independent Group Leader in the Department of Neuro-sensory Physiology, University Medical Center, Göttingen, Germany, since 2019



Major Research Interests

We couple metabolic labeling with mass spectrometry, super-resolution imaging, bioinformatics, and precision-designed molecular tools to investigate how the brain preserves molecular and cellular composition and function over the life span. The renewal and replacement of proteins and RNAs, spatial organization of synaptic components, and regulation of post-transcriptional processes responsible for neuronal activity are the key aspects of research in our lab. By examining how these mechanisms evolve with age and are lost in neurodegenerative disease, we aim to uncover the molecular logic behind synaptic integrity and plasticity. This systems-integration approach gives us a wide view of brain physiology, from molecular function to functional outcome, and sheds light on how long-term brain health is preserved or lost.


Homepage Department/Research Group
https://www.fornasierolab.uni-goettingen.de


Selected Recent Publications


  • Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions. Li W, Dasgupta A, Yang K, Wang S, Hemandhar-Kumar N, Chepyala SR, Yarbro JM, Hu Z, Salovska B, Fornasiero EF*, Peng J*, Liu Y*. Cell. 2025
    *Co-corresponding authors. https://www.ncbi.nlm.nih.gov/pubmed/40118046

  • DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning. Mohar B, Michel G, Wang YZ, Hernandez V, Grimm JB, Park JY, Patel R, Clarke M, Brown TA, Bergmann C, Gebis KK, Wilen AP, Liu B, Johnson R, Graves A, Tchumatchenko T, Savas JN, Fornasiero EF, Huganir RL, Tillberg PW, Lavis LD, Svoboda K, Spruston N. Nat Neurosci. 2025
    https://www.ncbi.nlm.nih.gov/pubmed/40164741

  • Spatial proteomics in neurons at single-protein resolution. Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, Opazo F, Fornasiero EF*, Jungmann R*. Cell. 2024
    *Co-corresponding authors.
    https://www.ncbi.nlm.nih.gov/pubmed/38552614

  • The DNA-PAINT palette: a comprehensive performance analysis of fluorescent dyes. Steen PR, Unterauer EM, Masullo LA, Kwon J, Perovic A, Jevdokimenko K, Opazo F, Fornasiero EF, Jungmann R. Nat Methods. 2024
    https://www.ncbi.nlm.nih.gov/pubmed/39112798

  • Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain. Kumar NH, Kluever V, Barth E, Krautwurst S, Furlan M, Pelizzola M, Marz M, Fornasiero EF. Nucleic Acids Res. 2024
    https://www.ncbi.nlm.nih.gov/pubmed/38471806

  • A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy. Queiroz Zetune Villa Real K, Mougios N, Rehm R, Sograte-Idrissi S, Albert L, Rahimi AM, Maidorn M, Hentze J, Martínez-Carranza M, Hosseini H, Saal KA, Oleksiievets N, Prigge M, Tsukanov R, Stenmark P, Fornasiero EF*, Opazo F*. Small Methods. 2023
    * Co-corresponding authors.
    https://www.ncbi.nlm.nih.gov/pubmed/37421204

  • Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration. Kluever V, Russo B, Mandad S, Kumar NH, Alevra M, Ori A, Rizzoli SO, Urlaub H, Schneider A, Fornasiero EF. Sci Adv. 2022
    https://www.ncbi.nlm.nih.gov/pubmed/35594347

    • For a complete list: https://pubmed.ncbi.nlm.nih.gov/?term=Fornasiero+EF&sort=date