Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Loren Andreas Ph.D.

Emmy Noether research group leader


  • 2007: BA in Chemistry, Oberlin College, Oberlin OH
  • 2014: Ph.D. in Physical Chemistry, Massachusetts Institute of Technology
  • 2014-2016: Postdoc, Ecole Normale Supérieure de Lyon, France)
  • 2016-2017: Group Leader, MPI-BPC
  • 2018-present: Emmy Noether Group Leader, MPI-BPC, now MPI-NAT



Major Research Interests

Our group is interested in the structural biology of membrane proteins and membrane-associated proteins such as misfolded proteins that aggregate on biological membranes. We have recently focused on viral ion channels and oligomeric states proteins implicated in neurodegeneration, such as alpha synuclein. We are interested in protein-ligand, protein-lipid, and protein-water interaction, including determination of the chemical structure through measurement of NMR parameters that depend on electronic structure. Our group leads developments in magic-angle-spinning NMR, with a focus on detection of protons. This allows preparations that include lipid bilayers, which is fundamentally important to our goal of understanding the functional states of membrane proteins in near-native conditions.


Homepage Department / Research Group

https://www.mpinat.mpg.de/de/andreas


Selected Recent Publications


  • Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, de Groot BL, Andreas LB , Becker S, Griesinger C & Schröder GF (2022) The 3D structure of lipidic fibrils of α-synuclein, Nat. Commun. 13, 6810
    https://doi.org/10.1038/s41467-022-34552-7

  • Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL,* Griesinger C, Andreas LB (2022) The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils, Nat. Commun. 13, 5385
    https://doi.org/10.1038/s41467-022-32797-w

  • Nimerovsky E,* Najbauer EE, Tekwani Movellan KA, Xue K, Becker S, Andreas LB* (2022), Modest Offset Difference Internuclear Selective Transfer via Homonuclear Dipolar Coupling, J. Phys. Chem. Lett
    https://doi.org/10.1021/acs.jpclett.1c03871

  • Xue K, Tekwani Movellan KA, Andreas LB* (2022) Orphan spin operator diagonal suppression, J. Magn. Reson. Open 100025
    https://doi.org/10.1016/j.jmro.2021.100025

  • Tekwani Movellan KA, Dervisoglu R, Becker S, Andreas LB* (2021) Pore bound water at the key residue histidine 37 in Influenza A M2, Angew. Chem. Int. Ed. Eng. 60, 24075-24079
    https://doi.org/10.1002/ange.202103955

  • Tekwani Movellan KA, Wegstroth M, Overkamp K, Leonov A, Becker S, Andreas LB* (2020) Imidazole–Imidazole Hydrogen Bonding in the pH-Sensing Histidine Side Chains of Influenza A M2,J. Am. Chem. Soc. 142, 2704-2708
    https://doi.org/10.1021/jacs.9b10984