Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Professor Dr. med. Dr. rer. nat. Tobias Brügmann


  • Since 2022: W2 Professor at Institute of Cardiovascular Physiology, University of Goettingen, Gemany
  • 2018–2022: Juniorprofessor at Institute of Cardiovascular Physiology, University of Goettingen, Gemany
  • 2013–2019: Dr. rer. nat.: Prof. Dr. Philipp Sasse, Institute of Physiology I, University of Bonn, Germany
  • 2017–2018: Working group leader, Institute of Physiology I, University of Bonn, Gemany
  • 2013–2018: Research assistant, Institute of Physiology I, University of Bonn, Gemany
  • 2008–2013: Dr. med.: Prof. Dr. Philipp Sasse, Institute of Physiology I, University of Bonn, Germany
  • 2005–2012: Human medicine, University of Bonn, Germany




Major Research Interests

Optogenetics, Muscle Physiology, Heart, Gastroparesis, Cardiac Arrhythmia, Laryngeal Pacemaking,
Heart failure, Atrial fibrillation, GPCR, electrophaysiology, excitation-contraction-coupling, skeletal muscle, smooth muscle cells



Homepage Department/Research Group
https://hkp.umg.eu/forschung/vegetative-optogenetik/


Selected Recent Publications


  • Wagdi A*, D Malan*, U Sathyanarayanan*, JS Beauchamp, M Vogt, D Zipf, T Beiert, B Mansuroglu, V Dusend, M Meininghaus, L Schneider, B Kalthof, JS Wiegert, GM König, E Kostenis, R Patejdl, P Sasse* & T Bruegmann* (2022). Selective optogenetic control of Gq signaling using human Neuropsin. Nature Communications 13, 1765. doi: 10.1038/s41467-022-29265-w

  • Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T* & Patejdl R* (2021) Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics 11, 5569-5584. doi: 10.7150/thno.53883

  • Bruegmann T*, Beiert T*, Vogt CC, Schrickel JW & Sasse P (2018) Optogenetic termination of atrial fibrillation in mice. Cardiovasc Res, 114, 713-723. doi: 10.1093/cvr/cvx250

  • Bruegmann T* Boyle PM,* Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA & Sasse P (2016) Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations. J Clin Invest, 126, 3894-3904. doi: 10.1172/JCI88950

  • Bruegmann T, Malan D, Hesse M, Beiert T, Fuegemann CJ, Fleischmann BK & Sasse P (2010) Optogenetic control of heart muscle in vitro and in vivo. Nat Methods, 7, 897-900. doi: 10.1038/nmeth.1512