Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Prof. Dr. med. Andreas Fischer


  • Since 2021 Full Professor and Chair of Clinical Chemistry and Laboratory Medicine at UMG
  • 2017 – 2021 Head of Division Vascular Signalling and Cancer, German Cancer Research Center (DKFZ) Heidelberg, Germany
  • 2014 – 2021 Physician at the Medical Clinic I, Heidelberg University Hospital, Germany
  • 2012 – 2017 Head of Helmholtz Young Investigators Group, German Cancer Research Center Heidelberg, Germany
  • 2007- 2012 Resident and Lecturer, Research Division Vascular Biology, Medical Faculty Mannheim, Heidelberg University, Germany
  • 2004 – 2007 Resident and Lecturer, Institute of Physiological Chemistry, Biocenter, University of Würzburg, Germany
  • 1996 – 2002 Studies of Medicine, University Medical Center Würzburg, Germany



Major Research Interests

Our research activities aim at studying signaling pathways that control blood vessel growth and angiocrine functions and its implications on organ function. We focus on cardiac and skeletal muscle as well as solid tumors. Our laboratory has identified Delta/Notch signaling in the endothelium as key player of angiogenesis, barrier control, metabolism and metastasis. We aim at understanding how endothelial cells orchestrate inflammation and tumor progression. Secondly, we aim at understanding the roles of endothelial cells as organ-specific sensors of plasma metabolites and how this alters the transcriptional landscape and the functions of the endothelium.


Homepage Department/Research Group

https://clinchem.umg.eu/ueber-uns/


Selected Recent Publications


  • Taylor J, Uhl L, Moll I, Hasan SS, Wiedmann L, Morgenstern J, Giaimo BD, Friedrich T, Alsina-Sanchis E, De Angelis Rigotti F, Mülfarth R, Kaltenbach S, Schenk D, Nickel F, Fleming T, Sprinzak D, Mogler C, Korff T, Billeter AT, Müller-Stich BP, Berriel Diaz M, Borggrefe T, Herzig S, Rohm M, Rodriguez-Vita J, Fischer A. Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Nat Cancer. 2023 Sep 25. [Epub ahead of print].

  • Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A. Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart. Circulation. 2018 Jun 12;137(24):2592-2608.

  • Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A. Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell. 2017 Mar 13;31(3):355-367.

  • Wiedmann L, De Angelis Rigotti F, Vaquero-Siguero N, Donato E, Espinet E, Moll I, Alsina-Sanchis E, Bohnenberger H, Fernandez-Florido E, Mülfarth R, Vacca M, Gerwing J, Conradi LC, Ströbel P, Trumpp A, Mogler C, Fischer A*, Rodriguez-Vita J*. HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. Nat Commun. 2023 Apr 24;14(1):2353.

  • Hasan SS, Jabs M, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne HJ, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A. Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med. 2020 Apr 7;12(4):e09271.

  • Weis EM, Puchalska P, Nelson AB, Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmüller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford PA, Fischer A. Ketone body oxidation increases cardiac endothelial cell proliferation. EMBO Mol Med. 2022 Apr 7;14(4):e14753.