Ehrenreich, Hannelore, Prof. Dr. Dr.


  • 1981 Doctor of Veterinary Medicine, University of Munich
  • 1983 Elective Period, University of Newcastle-upon-Tyne, England
  • 1985 Guest Lecturer, University of the Philippines, Manila
  • 1985 - 1986 Clinical Fellow, Department of Internal Medicine, University of Munich
  • 1987 Graduation (Medicine), University of Munich
  • 1987 - 1988 Residency, Department of Neurology, University of Munich
  • 1989 Doctor of Medicine, University of Munich
  • 1989 - 1991 Postdoctoral Fellow NIAID, NIH, Bethesda, MD, USA (Dr. A.S. Fauci)
  • 1992 - 1994 Residency, Departments of Neurology and Psychiatry, University of Göttingen
  • 1994 Habilitation (Neurology and Psychiatry)
  • 1994 - present Head, Clinical Neuroscience, Max Planck Institute of Experimental Medicine
  • 1995 - present Consultant & Professor of Neurology & Psychiatry, University of Göttingen
  • 2000 - 2002 Vice President, University of Göttingen
  • 2008 Professor of Biology and Psychology (Honorary), University of Göttingen
  • 2016 Member of the Leopoldina, German National Academy of Science



Major Research Interests

Translational Neuroscience

Research with particular focus on:

(1) Genetic and environmental underpinnings of neuropsychiatric diseases;

(2) Endogenous neuroprotection and neuroregeneration as therapeutic strategies for patients: Research centering on the brain erythropoietin system and hypoxia;

(3) Autoimmune and inflammatory processes contributing to neuropsychiatric phenotypes.



Homepage Department/Research Group

http://www.em.mpg.de/site/index.php?id=36



Selected Recent Publications


  • Wakhloo D, Scharkowski F, Curto Y, Butt UJ, Bansal V, Steixner-Kumar AA, Wüstefeld L, Rajput A, Arinrad S, Zillmann MR, Seelbach A, Hassouna I, Schneider K, Ibrahim AQ, Werner HB, Martens H, Miskowiak K, Wojcik SM, Bonn S, Nacher J, Nave KA, Ehrenreich H (2020) Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications 11: 1-12
  • Pan H, Steixner-Kumar AA, Seelbach A, Deutsch N, Ronnenberg A, Tapken D, Ahsen N, Mitjans M, Worthmann H, Trippe R, Klein-Schmidt C, Schopf N, Rentzsch K, Begemann M, Wienands J, Stöcker W, Weissenborn K, Hollmann M, Nave KA, Lühder F, Ehrenreich H (2020) Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: A translational study from chronic life stress to brain injury; Mol Psychiatry, doi: 10.1038/s41380-020-0672-1. [Epub ahead of print]
  • Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H (2019) Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model; Mol Psychiatry, doi: 10.1038/s41380-017-0011-3. [Epub ahead of print]
  • Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H*, Nave KA (2018) Microglia ablation alleviates myelin-associated catatonic signs in mice; J Clin Invest, 128(2):734-745. doi: 10.1172/JCI 97032. Epub 2017 Dec 18. *shared last authorship
  • Mitjans M, Seidel J, Begemann M, Bockhop F, Moya-Higueras J, Bansal V, Wesolowski J, Seelbach A, Ibáñez MI, Kovacevic F, Duvar O, Fañanás L, Wolf HU, Ortet G, Zwanzger P, Klein V, Lange I, Tänzer A, Dudeck M, Penke L, van Elst LT, Bittner RA, Schmidmeier R, Freese R, Müller-Isberner R, Wiltfang J, Bliesener T, Bonn S, Poustka L, Müller JL, Arias B, Ehrenreich H. (2018) Violent aggression predicted by multiple pre-adult environmental hits; Mol Psychiatry doi: 10.1038/s41380-018-0043-3. [Epub ahead of print]
  • Ehrenreich H, Mitjans M, Van der Auwera S, Centeno TP, Begemann M, Grabe HJ, Bonn S, Nave KA (2018) OTTO: A new strategy to extract mental disease-relevant combinations of GWAS hits from individuals; Mol Psychiatry, doi: 10.1038/mp.2016.208.
  • Bansal V, Mitjans M, Burik CAP, Linnér RK, Okbay A, Rietveld CA, Begemann M, Bonn S, Ripke S, de Vlaming R, Nivard MG, Ehrenreich H*, Koellinger PD (2018) Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. Nature Communications 9(1):3078. doi: 10.1038/s41467-018-05510-z. *shared last authorship
  • Castillo-Gomez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann W-H, Bertrand D, Hollmann M, Ehrenreich H (2017) All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry, doi: 10.1038/mp.2016.125.
  • Hassouna I, Ott C, Dahm L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, Hagemeyer N, Dittrich M, Rossetti MF, Kröhnert K, Hannke K, Boretius S, Zeug A, Höschen C, Dandekar T, Dere E, Neher E, Rizzoli SO, Nave KA, Sirén AL, Ehrenreich H (2016) Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus. Mol Psychiatry, doi: 10.1038/mp.2015.212.
  • Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H (2015) Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes. EMBO Mol Med. 7(12):1565-79.