Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Stadelmann-Nessler, Christine, Prof. Dr. med.

Professor of Neuropathology


  • Dr. med. univ. (M.D., University of Vienna, Austria)
  • Dr. med. (Humboldt-University Berlin, Germany)
  • Post-doctoral studies with Hans Lassmann, Brain Research Institute, Vienna, and Wolfgang Brück, Berlin and Göttingen
  • Since 2011: W3 professor of neuropathology, University Medical Center Göttingen



Major Research Interests


  • Pathogenesis of myelin and oligodendrocyte damage in demyelinating diseases, e.g., multiple sclerosis, acute disseminated encephalomyelitis, a.o.
  • Neuroaxonal damage in demyelinating diseases
  • Remyelination



Homepage Department/Research Group
http://www.neuropathologie.med.uni-goettingen.de/deutsch/forschung/ag-c.stadelmann.htm

Selected publications


  • Bergner CG, van der Meer F, Winkler W, Wrzos C, Türkmen M, Valizada E, Fitzner D, Hametner S, Hartmann A, Pfeifenbring S, Stoltenburg-Didinger G, Brück W, Nessler S, Stadelmann C. Microglia damage precedes major myelin destruction in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia 2019; Feb 11. doi: 10.1002/glia.23598
  • Masuda T*, Sankowski R*, Staszewski O*, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C., Prinz M. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature 2019; 566(7744):388-392.
  • Töpperwien M, van der Meer F, Stadelmann C., Salditt T. Three-dimensional virtual histology of human cerebellum by X-ray phase-contrast tomography. Proc Natl Acad Sci U S A 2018; Jul 3;115(27):6940-6945. doi: 10.1073/pnas.1801678115.
  • Fard MK*, van der Meer F*, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C#, Simons M#. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med. 2017 Dec 6;9(419). doi: 10.1126/scitranslmed.aam7816. *co-first; # co-last and corresponding
  • Lagumersindez-Denis N*, Wrzos C*, Mack M*, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Bruhl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C#, and Nessler S#. Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol 2017; 134(1):15-34. #corresponding authors
  • Singh S*, Dallenga T*, Winkler A, Roemer S, Maruschak B, Siebert H, Brück W#, Stadelmann C#. Relationship of acute axonal damage, Wallerian degeneration and clinical disability in multiple sclerosis. J Neuroinflammation 2017; Mar 17;14(1):57. doi: 10.1186/s12974-017-0831-8; # co-last
  • Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, Kuempfel T, Pellkofer H, Metz I, Bleckmann A, Hernández-Durán S, Schippling S, Rushing EJ, Frank S, Glatzel M, Matschke J, Hartmann C, Reifenberger G, Müller W, Schildhaus HU, Brück W, Stadelmann C. Diagnostic Red Flags: Steroid-Treated Malignant CNS Lymphoma Mimicking Autoimmune Inflammatory Demyelination. Brain Pathol 2017; Feb 18. doi: 10.1111/bpa.12496.
  • Albert M*, Barrantes-Freer A*, Lohrberg M, Antel JP, Prineas JW, Palkovits M, Wolff JR, Brück W, Stadelmann C. Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis. Brain Pathol 2016; Oct 5. doi: 10.1111/bpa.12450.
  • Rodriguez, E. G.*, C. Wegner*, M. Kreutzfeldt, K. Neid, D. R. Thal, T. Jurgens, W. Brück, C. Stadelmann#, D. Merkler#. Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination. Acta Neuropathol 2014; 128:231-246. # co-last
  • Wrzos, C., A. Winkler, I. Metz, D. M. Kayser, D. R. Thal, C. Wegner, W. Brück, S. Nessler, J. L. Bennett, C. Stadelmann. Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions. Acta Neuropathol 2014; 127:523-538.