Research Areas

In our group we work on modification, specific detection and conformational switching of oligonucleotides, peptides and proteins as well as examination of suitable model systems; influencing function and properties by synthesising analogues of biomolecules.
These include:

  • Synthesis of linear DNA base-stack models, application in DNA diagnostics, electron transfer and intercalation studies; enzyme mimetics
  • Molecular architecture: reversible helix and beta strand organisation, higher aggregates
  • Conformational switch in peptides and proteins
  • Stabilisation of Z-DNA; induction of bent DNA
  • Unnatural amino acids in peptides and proteins
  • DNA double helix detection