Research Area

Functional nucleic acids in organic and biomolecular chemistry for labeling, detection and visualization of biomolecules

  • RNA labeling with deoxyribozymes using DNA-catalyzed ligation chemistry

  • Synthesis of fluorescent labeling reagents, e.g. dye-labeled nucleoside triphosphates

  • Synthesis of paramagnetic nucleoside building blocks for EPR spectroscopy

  • In-vitro selection of fluorogenic RNA and DNA aptamers

  • Detection of natural modified nucleosides by fluorogenic bioorthogonal labeling

  • In-vitro selection of modification-specific deoxyribozymes

  • Structural and mechanistic analysis of nucleic acid catalysis